Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Chicago to San Ysidro, CA by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Chicago to San Ysidro?
The cheapest bus tickets from Chicago to San Ysidro start from $194. The average price for this route is around $277. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to San Ysidro?
The average bus trip duration from Chicago to San Ysidro is 2d 5h, covering a distance of 1726 miles (2783 km). The quickest bus can get you there in 2d 5h and is operated by Greyhound.
Which bus companies service the Chicago to San Ysidro route?
Several major train operators operate on this route with 9 trains available per day.
What is the earliest and latest departure time for the bus from Chicago to San Ysidro?
The earliest bus departs from Chicago to San Ysidro at 10:00am. And the latest bus departs at 11:50pm.
What are the CO₂ emissions for the bus trip from Chicago to San Ysidro?
A bus trip from Chicago to San Ysidro generates an estimated 70 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
01/10
$279
01/11
$265
Today
No data
01/13
$222
01/14
$221
01/15
$236
01/16
$260
01/17
$206
The cheapest trip from Chicago to San Ysidro, CA was searched and found on Jan 17, 2026 with a price of $206
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to San Ysidro, CA, as early as possible.
You can expect to pay from $206 to $282 for a bus ticket from Chicago to San Ysidro, CA based on the last 2 days. You can expect to find the cheapest price for the trip at $206 which is on 2026-01-17.
The cheapest trip from Chicago to San Ysidro, CA was searched and found on Jan 17, 2026 with a price of $206
