How much is the bus ticket from Chicago to San Ysidro?

The cheapest bus tickets from Chicago to San Ysidro start from $276. The average price for this route is around $395. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from Chicago to San Ysidro?

The average bus travel time from Chicago to San Ysidro is 2d 5h, covering a distance of 2783 km. The quickest bus can get you there in 2d 5h and is operated by Greyhound .

Which bus companies service the Chicago to San Ysidro route?

Several major bus companies operate on this route with 9 buses available per day.

What are the earliest and latest departure times for the bus from Chicago to San Ysidro?

The earliest bus departs from Chicago to San Ysidro at 10:00am. And the latest bus departs at 11:50pm.

What are the CO₂ emissions for the bus trip from Chicago to San Ysidro?

A bus trip from Chicago to San Ysidro generates an estimated 70 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

Bus Chicago to San Ysidro from $191 | Refundable Tickets

Next bus departures

Next departures for Chicago to San Ysidro on January 13
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	11:40pm	Chicago 95Th & Dan Ryan	2d 19h	5:10pm	San Ysidro Greyhound Bus Station	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	12:01pm	Downtown Greyhound Station	2d 4h	2:40pm	San Ysidro Bus terminal	Fastest
Greyhound Lines, Inc. + FlixBus	Bus	2:45pm	Downtown Greyhound Station	2d 6h	6:45pm	San Ysidro Bus terminal	No tags
	Bus	11:10pm	537-517 W. Jackson Blvd	2d 21h	6:20pm	San Ysidro Bus terminal	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:01pm	Downtown Greyhound Station	2d 7h	5:10pm	San Ysidro Greyhound Bus Station	No tags

Next departures for Chicago to San Ysidro on January 14
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	2:10pm	Chicago 95Th & Dan Ryan	2d 6h	6:20pm	San Ysidro Bus terminal	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	12:01pm	Downtown Greyhound Station	2d 4h	2:40pm	San Ysidro Bus terminal	Fastest
	Bus	2:45pm	Downtown Greyhound Station	2d 5h	6:20pm	San Ysidro Bus terminal	No tags
Greyhound Lines, Inc. + FlixBus	Bus	11:10pm	537-517 W. Jackson Blvd	2d 13h	10:35am	San Ysidro Bus terminal	No tags
	Bus	10:00am	537-517 W. Jackson Blvd	2d 10h	6:20pm	San Ysidro Bus terminal	No tags

Next departures for Chicago to San Ysidro on January 15
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	11:50pm	Chicago 95Th & Dan Ryan	2d 16h	2:40pm	San Ysidro Bus terminal	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	12:01pm	Downtown Greyhound Station	2d 4h	2:40pm	San Ysidro Bus terminal	Fastest
	Bus	2:45pm	Downtown Greyhound Station	2d 5h	6:20pm	San Ysidro Bus terminal	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:01pm	Downtown Greyhound Station	2d 7h	5:10pm	San Ysidro Greyhound Bus Station	No tags
	Bus	10:00am	537-517 W. Jackson Blvd	2d 10h	6:20pm	San Ysidro Bus terminal	No tags

Next departures for Chicago to San Ysidro on January 16
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	5:10pm	Chicago 95Th & Dan Ryan	2d 3h	6:20pm	San Ysidro Bus terminal	CheapestFastest
Greyhound Lines, Inc. + FlixBus	Bus	12:01pm	Downtown Greyhound Station	2d 4h	2:40pm	San Ysidro Bus terminal	No tags
	Bus	10:00am	537-517 W. Jackson Blvd	2d 10h	6:20pm	San Ysidro Bus terminal	No tags
FlixBus + Greyhound Lines, Inc.	Bus	4:30pm	Downtown Greyhound Station	2d 3h	6:20pm	San Ysidro Bus terminal	No tags
Greyhound Lines, Inc. + FlixBus	Bus	12:01pm	Downtown Greyhound Station	2d 7h	5:10pm	San Ysidro Greyhound Bus Station	No tags

Next departures for Chicago to San Ysidro on January 18
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	11:10pm	537-517 W. Jackson Blvd	2d 15h	12:20pm	San Ysidro Bus terminal	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	5:10pm	Chicago 95Th & Dan Ryan	2d 3h	6:20pm	San Ysidro Bus terminal	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	4:30pm	Downtown Greyhound Station	2d 3h	6:20pm	San Ysidro Bus terminal	No tags
	Bus	10:00am	537-517 W. Jackson Blvd	2d 10h	6:20pm	San Ysidro Bus terminal	No tags
FlixBus + Greyhound Lines, Inc.	Bus	11:05am	Chicago 95Th & Dan Ryan	2d 8h	5:10pm	San Ysidro Greyhound Bus Station	No tags

Next departures for Chicago to San Ysidro on January 19
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	12:01pm	Downtown Greyhound Station	2d 7h	5:10pm	San Ysidro Greyhound Bus Station	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	5:10pm	Chicago 95Th & Dan Ryan	2d 3h	6:45pm	San Ysidro Bus terminal	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	4:30pm	Downtown Greyhound Station	2d 4h	6:45pm	San Ysidro Bus terminal	No tags
	Bus	11:10pm	537-517 W. Jackson Blvd	2d 15h	12:20pm	San Ysidro Bus terminal	No tags
Greyhound Lines, Inc. + FlixBus	Bus	10:00am	537-517 W. Jackson Blvd	2d 10h	6:45pm	San Ysidro Bus terminal	No tags

Last refresh of the prices: Last Tuesday at 4:49 AM CST.

Get from Chicago to San Ysidro

This route is served by bus only

The journey takes about 2 days, 5 hours 35 minutes, and with fares starting at just $276, it presents an excellent value for a comfortable ride.

9bus per day

2d 5hAverage Duration

2783 kmDistance

70kgCO₂ emissions

Where are the popular stops in Chicago and San Ysidro?

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page Map
B
Chicago O'Hare International Airport
Visit page Map
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
Map
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
Map
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
Map
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Map

Stops in San Ysidro

A
San Ysidro Greyhound Bus Station
731 E San Ysidro Blvd, San Ysidro, CA 92173
Visit page Map

Compare bus companies

Greyhound

3.5/587,495 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Based on 87495 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $299

US bus companies:FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about travelling from Chicago to San Ysidro, CA by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from Chicago to San Ysidro?
The cheapest bus tickets from Chicago to San Ysidro start from $276. The average price for this route is around $395. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to San Ysidro?
The average bus travel time from Chicago to San Ysidro is 2d 5h, covering a distance of 2783 km. The quickest bus can get you there in 2d 5h and is operated by Greyhound.
Which bus companies service the Chicago to San Ysidro route?
Several major bus companies operate on this route with 9 buses available per day.
What are the earliest and latest departure times for the bus from Chicago to San Ysidro?
The earliest bus departs from Chicago to San Ysidro at 10:00am. And the latest bus departs at 11:50pm.
What are the CO₂ emissions for the bus trip from Chicago to San Ysidro?
A bus trip from Chicago to San Ysidro generates an estimated 70 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

01-09

$441

01-10

$398

Today

$378

01-12

No data

01-13

$316

01-14

$315

01-15

$336

01-16

$371

The cheapest trip from Chicago to San Ysidro, CA was searched and found on Jan 14, 2026 with a price of $315

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to San Ysidro, CA, as early as possible.

You can expect to pay from $315 to $470 for a bus ticket from Chicago to San Ysidro, CA based on the last 2 days. You can expect to find the cheapest price for the trip at $315 which is on 2026-01-14.