Next departures for Chicago to San Diego on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
San Diego (Old Town-FlixBus)
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
UCSD Health La Jolla Station
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
Downtown Greyhound Station
San Diego (Old Town-FlixBus)
No tags
Bus
537-517 W. Jackson Blvd
Greyhound Bus Stop
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
San Diego (Old Town-FlixBus)
No tags
Next departures for Chicago to San Diego on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
San Diego (Old Town-FlixBus)
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
UCSD Health La Jolla Station
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
Downtown Greyhound Station
San Diego (Old Town-FlixBus)
No tags
Bus
537-517 W. Jackson Blvd
Greyhound Bus Stop
No tags
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
San Diego (Old Town-FlixBus)
No tags
Next departures for Chicago to San Diego on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Downtown Greyhound Station
San Diego (Old Town-FlixBus)
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
UCSD Health La Jolla Station
Fastest
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
San Diego (Old Town-FlixBus)
No tags
Bus
537-517 W. Jackson Blvd
Greyhound Bus Stop
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Downtown Greyhound Station
UCSD Health La Jolla Station
No tags
Last refresh of the prices: Yesterday at 1:30 PM CST.
Compare 2 ways to go from Chicago to San Diego
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach San Diego. The journey takes about 2 days, 7 hours 45 minutes and with fares starting at just $118, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Chicago to San Diego, CA, US by bus
What is the distance between Chicago and San Diego?
About 1729 miles (2788 km) separate Chicago and San Diego.
What are the departure and arrival stations when taking the bus from Chicago to San Diego?
If you're headed to San Diego from Chicago, chances are that your bus will leave from Downtown Greyhound Station and arrive at Mission Valley Sheraton. These are the main departure and arrival locations on this route, but you can also find other options that could better fit your plans.
What are the best sights and things to do in San Diego?
Once in San Diego, you can start exploring the city and discover its surroundings. The top sights and things to do are Coronado, The Gaslamp Quarter, San Diego Zoo, Torrey Pines Gliderport and USS Midway Museum.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/22
$425
11/23
$432
Today
$479
11/25
$539
11/26
$496
11/27
$306
11/28
$299
11/29
$156
The cheapest trip from Chicago to San Diego, CA, US was searched and found on Nov 29, 2025 with a price of $156
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to San Diego, CA, US, as early as possible.
You can expect to pay from $156 to $539 for a bus ticket from Chicago to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $156 which is on 2025-11-29.
What's the cheapest way to go from Chicago to San Diego, CA, US?
The bus is the cheapest travel choice for this destination
The cheapest trip from Chicago to San Diego, CA, US was searched and found on Nov 29, 2025 with a price of $156
The bus is the cheapest travel choice for this destination
