Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | 537-517 W. Jackson Blvd | Greyhound Bus Stop | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | UCSD Health La Jolla Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Downtown Greyhound Station | San Diego (Old Town-FlixBus) | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Downtown Greyhound Station | San Diego (Old Town-FlixBus) | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Downtown Greyhound Station | UCSD Health La Jolla Station | No tags |
Last refresh of the prices: Today at 13:22 CST.
Compare 2 ways to travel from Chicago to San Diego
Among the sustainable travel choices, the bus stands out as a good way to reach San Diego. The journey takes about 2 days, 7 hours 45 minutes and with fares starting at just £93, it presents an excellent value for a comfortable ride.
Where are the popular stops in Chicago and San Diego?
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
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Frequently asked questions about travelling by bus from Chicago to San Diego, CA, US
What's the distance between Chicago and San Diego by coach?
The distance between Chicago and San Diego by coach is approximately 1729 miles (2788 km).
What is the best way to go from Chicago to San Diego without flying?
You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to San Diego, CA, US was searched and found on 22 Nov 2025 with a price of £102To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to San Diego, CA, US as early as possible.
You can expect to pay from £102 to £358 for a bus ticket from Chicago to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at £102, which is on 2025-11-22.
What's the cheapest way to go from Chicago to San Diego, CA, US?
The bus is the cheapest travel choice for this destination
