Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | UCSD Health La Jolla Station | Cheapest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Chicago 95Th & Dan Ryan | UCSD Health La Jolla Station | Fastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Downtown Greyhound Station | San Diego (Old Town-FlixBus) | No tags | ||||
 | Bus | 537-517 W. Jackson Blvd | Greyhound Bus Stop | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Downtown Greyhound Station | San Diego (Old Town-FlixBus) | No tags |
Last refresh of the prices: Yesterday at 10:25 AM CST.
Compare 2 ways to go from Chicago to San Diego
Among the sustainable travel choices, the bus stands out as a good way to reach San Diego. The journey takes about 2 days, 7 hours 45 minutes, and with fares starting at just $169, it presents an excellent value for a comfortable ride.
Where are the popular stops in Chicago and San Diego?
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
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Frequently asked questions about travelling from Chicago to San Diego, CA, US by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Chicago to San Diego?
The cheapest bus tickets from Chicago to San Diego start from $169. The average price for this route is around $409. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Chicago to San Diego?
The average bus travel time from Chicago to San Diego is 2d 7h, covering a distance of 2785 km. The quickest bus can get you there in 2d 5h and is operated by Greyhound.
Which bus companies service the Chicago to San Diego route?
What are the earliest and latest departure times for the bus from Chicago to San Diego?
The earliest bus departs from Chicago to San Diego at 12:15am. And the latest bus departs at 11:50pm.
What are the CO₂ emissions for the bus trip from Chicago to San Diego?
A bus trip from Chicago to San Diego generates an estimated 70 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Chicago to San Diego?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87387 reviews.
Which bus company has the best Wi-Fi from Chicago to San Diego?
Based on Busbud reviews, the bus company FlixBus has the highest Wi-Fi rating with a score of 2.7.
Which bus company has the best on-time performance from Chicago to San Diego?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Chicago to San Diego?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Chicago to San Diego, CA, US was searched and found on Dec 7, 2025 with a price of $252To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to San Diego, CA, US, as early as possible.
You can expect to pay from $252 to $738 for a bus ticket from Chicago to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $252 which is on 2025-12-07.
What's the cheapest way to go from Chicago to San Diego, CA, US?
The bus is the cheapest travel choice for this destination
