Find coaches from Syracuse, US to Chicago

Next departures

Next departures from Syracuse to Chicago on 3 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
    		Syracuse (Regional Transportation Center)
    		Chicago 95Th & Dan RyanCheapest
    Greyhound Lines, Inc.
      		Syracuse (Regional Transportation Center)
      		Downtown Greyhound StationFastest
      Greyhound Lines, Inc.
        		Syracuse (Regional Transportation Center)
        		Downtown Greyhound StationNo tags
        FlixBus + Greyhound Lines, Inc.
          		Syracuse (Regional Transportation Center)
          		Downtown Greyhound StationNo tags
          Greyhound Lines, Inc.
            		Syracuse (Regional Transportation Center)
            		537-517 W. Jackson BlvdNo tags

            Last refresh of the prices: Today at 6:16 AM EST.

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            Compare 2 ways to travel from Syracuse to Chicago

            We recommend taking the bus

            Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 1 day, 5 hours and with fares starting at just US$57, it presents an excellent value for a comfortable ride.

            9bus per day
            1d 5hAverage duration
            952 kmDistance
            24kgCO₂ emissions
            Bus
            		Average priceUS$57 - US$232Average duration1d 5h
            24kg CO₂e
            Train
            		Average priceUS$60 - US$215Average duration13h 7m
            86kg CO₂e

            Bus Syracuse, US to Chicago: Trip Overview

            Average ticket priceUS$100
            Average bus trip duration1d 5h
            Number of daily buses9
            Earliest bus departure02:00
            Distance952 km
            Latest bus departure21:00

            Syracuse to Chicago Bus

            Busbud helps you find a bus from Syracuse to Chicago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

            We make sure you can find a bus service from Syracuse to Chicago from the most reliable bus companies operating this trip.

            Discover how much the bus trip from Syracuse to Chicago will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

            Frequently asked questions on the trip Syracuse, US - Chicago

            1. How much does a bus ticket from Syracuse to Chicago cost?

              The bus ticket price from Syracuse to Chicago starts at US$57. The best way to find cheap bus tickets from Syracuse to Chicago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

            2. How long is the bus ride from Syracuse to Chicago?

              The average travel time between Syracuse and Chicago is around 1d 5h, although the fastest bus will take about 16h 35m. This is the time it takes to travel the 954 km that separates the two cities.

            3. How many daily bus connections are there between Syracuse and Chicago?

              The number of buses from Syracuse to Chicago can differ depending on the day of the week. On average, there are 9 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Syracuse to Chicago by comparing and selecting the bus that fits your travel style and budget on Busbud.

            4. Which bus companies travel from Syracuse to Chicago?

              When taking the bus from Syracuse to Chicago, you can travel comfortably and safely with Greyhound, FlixBus, New York Trailways.

            5. What are the departure and arrival stations when taking the bus from Syracuse to Chicago?

              Buses travelling between Syracuse and Chicago leave from Regional Transportation Center or Syracuse Airport and arrive at Downtown Greyhound Station, Chicago O'Hare International Airport, Polk St & Canal St.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            31/10
            US$174
            01/11
            US$87
            Today
            US$91
            03/11
            US$166
            04/11
            US$115
            05/11
            US$62
            06/11
            US$102
            07/11
            US$105
            busbud logoThe cheapest trip from Syracuse, US to Chicago was searched and found on 05 Nov 2025 with a price of US$62

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Chicago as early as possible.

            You can expect to pay from US$62 to US$210 for a bus ticket from Syracuse, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$62, which is on 2025-11-05.

            About Bus Travel

            Bus Travel Tips

            Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Syracuse and Chicago!

            Start sightseeing the minute your bus leaves the station. If you're on the night bus from Syracuse to Chicago, get comfy and count the stars.

            Buses have the smallest carbon footprint of all motorized transport modes. A bus going from Syracuse to Chicago will emit half the CO2 emitted by a train, and radically less than a car or an airplane.

            Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Syracuse to Chicago.

            Did you know?

            Did you know that 80% of the buses in North America are equipped with WiFi and power outlets ? And 60% of bus travellers have used their electronic device on board during 2014.

            It takes 27 hours to go by bus from Lima to Cusco, one of the craziest bus trips on the world. This route is used daily by locals and backpackers.

            Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

            What's the cheapest way to go from Syracuse, US to Chicago?

            busbud logoThe bus is the cheapest travel choice for this destination

            Will you be returning to Syracuse, US by bus?

            Bus from Chicago to Syracuse, US

            You can also go to Chicago by train

            Train from Syracuse, US to Chicago

            Why choose Busbud?

            The Best Way To Book Bus and Train Tickets

            Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With several language and currency options available, Busbud seeks to cater to international bus travellers no matter where they are in the world. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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