What is the travel distance from Syracuse to Chicago?

The distance covered from Syracuse to Chicago is 954 km (592 miles).

What are the departure and arrival locations for buses traveling from Syracuse to Chicago?

Buses traveling this route start their trip at Regional Transportation Center, in Syracuse, and end it at Downtown Greyhound Station, in Chicago.

Bus Syracuse to Chicago from $137 | Refundable Tickets

Next bus departures

Next departures for Syracuse to Chicago on November 24
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
FlixBus + Greyhound Lines, Inc.	Bus	1:55pm	Syracuse (Regional Transportation Center)	1d 7h	8:05pm	Downtown Greyhound Station	CheapestFastest
FlixBus + Greyhound Lines, Inc.	Bus	1:55pm	Syracuse (Regional Transportation Center)	1d 9h	10:25pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Syracuse to Chicago on November 25
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:30am	Syracuse (Regional Transportation Center)	16h 35m	8:05pm	Downtown Greyhound Station	CheapestFastest
	Bus	9:25am	Syracuse (Regional Transportation Center)	1d 1h	10:00am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	1:55pm	Syracuse (Regional Transportation Center)	1d 7h	8:05pm	Downtown Greyhound Station	No tags
	Bus	4:30am	Syracuse (Regional Transportation Center)	1d 4h	7:50am	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	9:25am	Syracuse (Regional Transportation Center)	1d 5h	1:25pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Syracuse to Chicago on November 26
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:30am	Syracuse (Regional Transportation Center)	1d 4h	7:50am	537-517 W. Jackson Blvd	Cheapest
	Bus	4:30am	Syracuse (Regional Transportation Center)	16h 35m	8:05pm	Downtown Greyhound Station	Fastest
	Bus	9:25am	Syracuse (Regional Transportation Center)	1d 1h	10:00am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	1:55pm	Syracuse (Regional Transportation Center)	1d 7h	8:05pm	Downtown Greyhound Station	No tags
	Bus	9:25am	Syracuse (Regional Transportation Center)	1d 5h	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Syracuse to Chicago on November 27
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:30am	Syracuse (Regional Transportation Center)	16h 35m	8:05pm	Downtown Greyhound Station	CheapestFastest
	Bus	9:25am	Syracuse (Regional Transportation Center)	1d 1h	10:00am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	1:55pm	Syracuse (Regional Transportation Center)	1d 7h	8:05pm	Downtown Greyhound Station	No tags
	Bus	4:30am	Syracuse (Regional Transportation Center)	1d 4h	7:50am	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	9:25am	Syracuse (Regional Transportation Center)	1d 5h	1:25pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Syracuse to Chicago on November 28
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:30am	Syracuse (Regional Transportation Center)	16h 35m	8:05pm	Downtown Greyhound Station	CheapestFastest
	Bus	9:25am	Syracuse (Regional Transportation Center)	1d 1h	10:00am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	1:55pm	Syracuse (Regional Transportation Center)	1d 7h	8:05pm	Downtown Greyhound Station	No tags
	Bus	4:30am	Syracuse (Regional Transportation Center)	1d 4h	7:50am	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	9:25am	Syracuse (Regional Transportation Center)	1d 5h	1:25pm	Chicago 95Th & Dan Ryan	No tags

Next departures for Syracuse to Chicago on November 29
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:30am	Syracuse (Regional Transportation Center)	18h 55m	10:25pm	Chicago 95Th & Dan Ryan	Cheapest
	Bus	4:30am	Syracuse (Regional Transportation Center)	16h 35m	8:05pm	Downtown Greyhound Station	Fastest
	Bus	9:25am	Syracuse (Regional Transportation Center)	1d 1h	10:00am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	1:55pm	Syracuse (Regional Transportation Center)	1d 7h	8:05pm	Downtown Greyhound Station	No tags
	Bus	4:30am	Syracuse (Regional Transportation Center)	1d 4h	7:50am	537-517 W. Jackson Blvd	No tags

Next departures for Syracuse to Chicago on November 30
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:30am	Syracuse (Regional Transportation Center)	1d 4h	7:50am	537-517 W. Jackson Blvd	Cheapest
	Bus	4:30am	Syracuse (Regional Transportation Center)	16h 35m	8:05pm	Downtown Greyhound Station	Fastest
	Bus	9:25am	Syracuse (Regional Transportation Center)	1d 1h	10:00am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	1:55pm	Syracuse (Regional Transportation Center)	1d 7h	8:05pm	Downtown Greyhound Station	No tags
	Bus	9:25am	Syracuse (Regional Transportation Center)	1d 5h	2:10pm	537-517 W. Jackson Blvd	No tags

Next departures for Syracuse to Chicago on December 1
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
	Bus	4:30am	Syracuse (Regional Transportation Center)	16h 35m	8:05pm	Downtown Greyhound Station	CheapestFastest
	Bus	9:25am	Syracuse (Regional Transportation Center)	1d 1h	10:00am	Downtown Greyhound Station	No tags
FlixBus + Greyhound Lines, Inc.	Bus	1:55pm	Syracuse (Regional Transportation Center)	1d 7h	8:05pm	Downtown Greyhound Station	No tags
	Bus	4:30am	Syracuse (Regional Transportation Center)	1d 4h	7:50am	537-517 W. Jackson Blvd	No tags
Greyhound Lines, Inc. + FlixBus	Bus	9:25am	Syracuse (Regional Transportation Center)	1d 5h	1:25pm	Chicago 95Th & Dan Ryan	No tags

Last refresh of the prices: Today at 3:31 AM EST.

Compare 2 ways to go from Syracuse to Chicago

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 1 day, 5 hours, and with fares starting at just $82, it presents an excellent value for a comfortable ride.

9bus per day

1d 5hAverage Duration

952 kmDistance

24kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$82 - $458	Average Duration1d 5h	CO₂ emissions 24kg CO₂e
Train	Average Price$86 - $310	Average Duration13h 7m	CO₂ emissions 86kg CO₂e

Where are the popular stops in Syracuse and Chicago?

Stops in Syracuse

A
Regional Transportation Center
1 Walsh Circle Ste 30, Syracuse, NY 13208
Visit page
B
Syracuse Airport
Visit page
C
Syracuse University
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210
Visit page
D
Syracuse University - Lyman Hall
College Place, Syracuse, NY 13210, USA
E
New York State Fairgrounds
581 State Fair Blvd, Syracuse, NY 13209, USA
F
Syracuse, NY
349-399 US-11, Syracuse, NY 13202, USA

Stops in Chicago

A
Downtown Greyhound Station
630 W Harrison St, Chicago, IL 60607, USA
Visit page
B
Chicago O'Hare International Airport
Visit page
C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA
D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA
E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA
F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA

Compare bus companies

Greyhound

3.5/587,393 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

FlixBus

3.5/511,422 reviews

Staff4.2

Timeliness3.9

Cleanliness4.1

Wifi2.7

New York Trailways

4/54,412 reviews

Staff4.6

Timeliness4.1

Cleanliness4.5

Wifi3.2

Adirondack Trailways

4/51,126 reviews

Staff4.6

Timeliness4.3

Cleanliness4.8

Wifi2.4

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling from Syracuse, US to Chicago by bus

What is the travel distance from Syracuse to Chicago?
The distance covered from Syracuse to Chicago is 954 km (592 miles).
What are the departure and arrival locations for buses traveling from Syracuse to Chicago?
Buses traveling this route start their trip at Regional Transportation Center, in Syracuse, and end it at Downtown Greyhound Station, in Chicago.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-22

$251

11-23

$230

Today

$246

11-25

$304

11-26

$272

11-27

$217

11-28

$229

11-29

$316

The cheapest trip from Syracuse, US to Chicago was searched and found on Nov 27, 2025 with a price of $217

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Chicago, as early as possible.

You can expect to pay from $217 to $501 for a bus ticket from Syracuse, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $217 which is on 2025-11-27.