Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal de Autobuses de San Nicolas | Terminal Sur | Cheapest | ||||
| Bus | Terminal de Autobuses de San Nicolas | Terminal Sur | Fastest | ||||
| Bus | Terminal de Autobuses de San Nicolas | Terminal Sur | No tags | ||||
| Bus | Terminal de Autobuses de San Nicolas | Terminal Sur | No tags | ||||
| Bus | Terminal de Autobuses de San Nicolas | Terminal Sur | No tags |
Last refresh of the prices: Yesterday at 3:57 PM -03.
Get from San Nicolás to Santiago
The journey takes about 4 hours 16 minutes, and with fares starting at just R 197, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Nicolás and Santiago?
Stops in San Nicolás
- A
Terminal de Autobuses de San Nicolas
N-50 312-448, San Nicolás, Región del Bío Bío, Chile
Stops in Santiago
- ASantiago - Av Libertador Bernardo O'Higgins 3850, Santiago, Estación Central, Región Metropolitana, Chile
- B
San Borja
San Francisco de Borja 199-225, Santiago, Estación Central, Región Metropolitana, Chile - CTucapel Jiménez 21, 8340528 Santiago, Región Metropolitana, Chile
- DPdte. Riesco 6391-6399, Las Condes, Región Metropolitana, Chile
- EAv. Gral. Oscar Bonilla 418, Lo Prado, Región Metropolitana, Chile
- F
Santiago
Juan Esteban Montero 5688, Las Condes, Las Condes, Región Metropolitana, Chile
Compare bus companies
Based on 157 reviews, the company was rated 3.8 stars on Busbud. Travellers were especially satisfied with the cleanliness and the ticket access but often complained with the Wi-Fi. Eme Bus ticket prices on this trip start at R 197
Frequently asked questions about travelling from San Nicolás, CL to Santiago, CL by bus
How much does a bus ticket from San Nicolás to Santiago cost?
The bus ticket price from San Nicolás to Santiago starts at R 197. The best way to find cheap bus tickets from San Nicolás to Santiago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from San Nicolás to Santiago?
The average travel time between San Nicolás and Santiago is around 4h 16m, although the fastest bus will take about 4h 16m. This is the time it takes to travel the 374 km that separates the two cities.
How many daily bus connections are there between San Nicolás and Santiago?
The number of buses from San Nicolás to Santiago can differ depending on the day of the week. On average, there are 3 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from San Nicolás to Santiago by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from San Nicolás to Santiago?
When taking the bus from San Nicolás to Santiago, you can travel comfortably and safely with Eme Bus.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Nicolás, CL to Santiago, CL was searched and found on 27 Nov 2025 with a price of R 162To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Nicolás, CL to Santiago, CL as early as possible.
You can expect to pay from R 162 to R 325 for a bus ticket from San Nicolás, CL to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at R 162, which is on 2025-11-27.
