Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Terminal de Autobuses de San Nicolas | Terminal Sur | Cheapest | ||||
| Bus | Terminal de Autobuses de San Nicolas | Terminal Sur | Fastest | ||||
| Bus | Terminal de Autobuses de San Nicolas | Terminal Sur | No tags | ||||
| Bus | Terminal de Autobuses de San Nicolas | Terminal Sur | No tags | ||||
| Bus | Terminal de Autobuses de San Nicolas | Terminal Sur | No tags |
Last refresh of the prices: Last Monday at 12:06 -03.
Get from San Nicolás to Santiago
The journey takes about 4 hours 16 minutes, and with fares starting at just £9, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Nicolás and Santiago?
Stops in San Nicolás
- A
Terminal de Autobuses de San Nicolas
N-50 312-448, San Nicolás, Región del Bío Bío, Chile
Stops in Santiago
- ASantiago - Av Libertador Bernardo O'Higgins 3850, Santiago, Estación Central, Región Metropolitana, Chile
- B
San Borja
San Francisco de Borja 199-225, Santiago, Estación Central, Región Metropolitana, Chile - CTucapel Jiménez 21, 8340528 Santiago, Región Metropolitana, Chile
- DPdte. Riesco 6391-6399, Las Condes, Región Metropolitana, Chile
- EAv. Gral. Oscar Bonilla 418, Lo Prado, Región Metropolitana, Chile
- F
Zapadores
Los Zapadores 608, Recoleta, Región Metropolitana, Chile
Compare bus companies
Based on 157 reviews, the company was rated 3.8 stars on Busbud. Travellers were especially satisfied with the cleanliness and the ticket access but often complained with the Wi-Fi. Eme Bus ticket prices on this trip start at £9
Frequently asked questions about travelling by bus from San Nicolás, CL to Santiago, CL
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from San Nicolás to Santiago?
The cheapest coach tickets from San Nicolás to Santiago start from £9. The average price for this route is around £11. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from San Nicolás to Santiago?
The average bus journey time from San Nicolás to Santiago is 4h 16m, covering a distance of 228 miles. The fastest bus can take you there in 4h 16m and is operated by Eme Bus.
Which bus companies service the San Nicolás to Santiago route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from San Nicolás to Santiago?
The earliest bus departs from San Nicolás to Santiago at 00:10. And the latest bus departs at 14:30.
What are the CO₂ emissions for the bus trip from San Nicolás to Santiago?
A bus journey from San Nicolás to Santiago produces an estimated 9 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Nicolás, CL to Santiago, CL was searched and found on 29 Dec 2025 with a price of £9To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Nicolás, CL to Santiago, CL as early as possible.
You can expect to pay from £9 to £15 for a bus ticket from San Nicolás, CL to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at £9, which is on 2025-12-29.
