Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | San Antonio Bus Station | Downtown Transit Center | Cheapest | ||||
Greyhound Lines Mexico + Greyhound Lines, Inc. | Bus | San Antonio Bus Station | Indianapolis Bus Station | Fastest | ||||
Greyhound Lines Mexico + Greyhound Lines, Inc. | Bus | San Antonio Bus Station | Indianapolis Bus Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | San Antonio Bus Station | Indianapolis Bus Station | No tags | ||||
Valley Transit + Greyhound Lines, Inc. | Bus | San Antonio Bus Station | Indianapolis Bus Station | No tags |
Last refresh of the prices: Last Friday at 5:16 PM CST.
Compare 2 ways to travel from San Antonio to Indianapolis
Among the sustainable travel choices, the bus stands out as a good way to reach Indianapolis. The journey takes about 1 day, 6 hours 30 minutes and with fares starting at just R 2 222, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Antonio and Indianapolis?
Stops in San Antonio
- A500 N St Mary's St, San Antonio, TX 78205, USA
- B7914 Interstate 35 Access Rd, San Antonio, TX 78224, USA
- C165 Bowie St, San Antonio, 78205
- D4407 S PanAm Expy #101, San Antonio, TX 78225, USA
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Frequently asked questions about travelling from San Antonio, US to Indianapolis by bus
How much does a bus ticket from San Antonio to Indianapolis cost?
The bus ticket price from San Antonio to Indianapolis starts at R 2 222. The best way to find cheap bus tickets from San Antonio to Indianapolis is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from San Antonio to Indianapolis?
The average travel time between San Antonio and Indianapolis is around 1d 6h, although the fastest bus will take about 1d 2h. This is the time it takes to travel the 1611 km that separates the two cities.
How many daily bus connections are there between San Antonio and Indianapolis?
The number of buses from San Antonio to Indianapolis can differ depending on the day of the week. On average, there are 13 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from San Antonio to Indianapolis by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from San Antonio to Indianapolis?
When taking the bus from San Antonio to Indianapolis, you can travel comfortably and safely with Greyhound, Valley Transit, FlixBus.
What are the departure and arrival stations when taking the bus from San Antonio to Indianapolis?
Buses travelling between San Antonio and Indianapolis leave from San Antonio Bus Station or Tornado I-35 and arrive at Greyhound Amtrak Station.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Antonio, US to Indianapolis was searched and found on 26 Nov 2025 with a price of R 2 759To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Antonio, US to Indianapolis as early as possible.
You can expect to pay from R 2 759 to R 4 668 for a bus ticket from San Antonio, US to Indianapolis based on the last 2 days. You can expect to find the cheapest price for the trip at R 2 759, which is on 2025-11-26.
What's the cheapest way to go from San Antonio, US to Indianapolis?
The bus is the cheapest travel choice for this destination
