How much does a bus ticket from Rome to Isernia cost?

The bus ticket price from Rome to Isernia starts at US$20. The best way to find cheap bus tickets from Rome to Isernia is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

How long is the bus ride from Rome to Isernia?

The average travel time between Rome and Isernia is around 6h 44m, although the fastest bus will take about 2h 35m. This is the time it takes to travel the 150 km that separates the two cities.

How many daily bus connections are there between Rome and Isernia?

The number of buses from Rome to Isernia can differ depending on the day of the week. On average, there are 2 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Rome to Isernia by comparing and selecting the bus that fits your travel style and budget on Busbud.

Which bus companies travel from Rome to Isernia?

When taking the bus from Rome to Isernia, you can travel comfortably and safely with FlixBus, FlixBus.

What are the departure and arrival stations when taking the bus from Rome to Isernia?

Buses travelling between Rome and Isernia leave from Rome Ciampino Airport or Rome Tiburtina Bus Station and arrive at Isernia.

Bus Rome to Isernia from US$17 | Refundable Tickets

Next departures

Next departures from Rome to Isernia on 2 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
05:10	Rome Tiburtina Bus Station	6h 14m	11:24	Isernia	CheapestFastest
04:05	Rome Fiumicino Airport	7h 19m	11:24	Isernia	No tags
04:40	Aeroporto Ciampino Airport (CIA)	6h 44m	11:24	Isernia	No tags

Next departures from Rome to Isernia on 5 November
Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
05:10	Rome Tiburtina Bus Station	6h 14m	11:24	Isernia	CheapestFastest
04:05	Rome Fiumicino Airport	7h 19m	11:24	Isernia	No tags
04:40	Aeroporto Ciampino Airport (CIA)	6h 44m	11:24	Isernia	No tags

Last refresh of the prices: Today at 12:00 PM CET.

Compare 3 ways to travel from Rome to Isernia

We recommend carpooling

Among the sustainable travel choices, the carpool stands out as a good way to reach Isernia. The journey takes about 2 hours and with fares starting at just US$11, it presents an excellent value for a comfortable ride.

5carpool per day

2hAverage duration

149 kmDistance

6kgCO₂ emissions

	Average price	Average duration	CO₂ emissions
Bus	Average priceUS$20 - US$69	Average duration6h 44m	CO₂ emissions 4kg CO₂e
Train	Average priceUS$21 - US$22	Average duration2h 48m	CO₂ emissions 4kg CO₂e
Carpool	Average priceUS$11 - US$21	Average duration2h	CO₂ emissions 6kg CO₂e

Bus Rome to Isernia: Trip Overview

Average ticket priceUS$31

Average bus trip duration6h 44m

Number of daily buses2

Earliest bus departure02:45

Distance146 km

Latest bus departure13:00

Compare bus companies

FlixBus

3.5/511 146 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

WiFi2.7

FlixBus

3.5/511 146 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

WiFi2.7

IT Bus Companies: FlixBus, BlaBlaCar Bus, Rede Expressos, Trenitalia, MarinoBus, Infobus, Itabus

Rome to Isernia Bus

Busbud shows you the best bus ticket fares and bus schedules so you can easily plan and book a trip by bus from Rome to Isernia.

Bus service from Rome to Isernia will be provided by the most trusted bus companies.

From cheap bus tickets to more luxurious buses travelling from Rome to Isernia, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

Where are the popular stops in Rome and Isernia?

Stops in Rome

A - Rome Ciampino Airport

B - Rome Tiburtina Bus Station

C - Rome Fiumicino Airport

D - Castro Pretorio

E - Roma

F - Anagnina

Stops in Isernia

A - Isernia

Frequently asked questions on the trip Rome - Isernia

How much does a bus ticket from Rome to Isernia cost?
The bus ticket price from Rome to Isernia starts at US$20. The best way to find cheap bus tickets from Rome to Isernia is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Rome to Isernia?
The average travel time between Rome and Isernia is around 6h 44m, although the fastest bus will take about 2h 35m. This is the time it takes to travel the 150 km that separates the two cities.
How many daily bus connections are there between Rome and Isernia?
The number of buses from Rome to Isernia can differ depending on the day of the week. On average, there are 2 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Rome to Isernia by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Rome to Isernia?
When taking the bus from Rome to Isernia, you can travel comfortably and safely with FlixBus, FlixBus.
What are the departure and arrival stations when taking the bus from Rome to Isernia?
Buses travelling between Rome and Isernia leave from Rome Ciampino Airport or Rome Tiburtina Bus Station and arrive at Isernia.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

30/10

No data

31/10

US$25

Today

US$50

02/11

US$33

03/11

US$20

04/11

US$27

05/11

US$30

06/11

No data

The cheapest trip from Rome to Isernia was searched and found on 03 Nov 2025 with a price of US$20

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Isernia as early as possible.

You can expect to pay from US$20 to US$63 for a bus ticket from Rome to Isernia based on the last 2 days. You can expect to find the cheapest price for the trip at US$20, which is on 2025-11-03.

About Bus Travel

Bus Travel Tips

If you're abroad, study some local language. Not only could it get you out of a pickle during your bus trip from Rome to Isernia but it'll also be endearing to native speakers who will surely appreciate your effort.

Much more than a mere vehicle taking you from Rome to Isernia, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from Rome to Isernia that are otherwise impossible to come by with a plane.

Tune out to the fine sounds of your best music playlist on your bus trip from Rome to Isernia while indulging in miles on end of beautiful scenic views.

Did you know?

Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

Will you be returning to Rome by bus?

Bus from Isernia to Rome

You can also go to Isernia by train

Train from Rome to Isernia

Top travelled bus routes

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud helps you easily search, compare and book intercity bus tickets on a worlwide scale with our comprehensive list of bus routes and schedules. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

Find coaches from Rome to Isernia