How much does a bus ticket from Rome to Isernia cost?

The bus ticket price from Rome to Isernia starts at $21. The best way to find cheap bus tickets from Rome to Isernia is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

How long is the bus ride from Rome to Isernia?

The average travel time between Rome and Isernia is around 6h 44m, although the fastest bus will take about 6h 9m. This is the time it takes to travel the 93 miles that separates the two cities.

How many daily bus connections are there between Rome and Isernia?

The number of buses from Rome to Isernia can differ depending on the day of the week. On average, there are 2 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Rome to Isernia by comparing and selecting the bus that fits you travel style and budget on Busbud.

Which bus companies travel from Rome to Isernia?

When taking the bus from Rome to Isernia, you can travel comfortably and safely with FlixBus.

What are the departure and arrival stations when taking the bus from Rome to Isernia?

Buses traveling between Rome and Isernia leave from Rome Tiburtina Bus Station or Rome Ciampino Airport and arrive at Isernia.

Bus Rome to Isernia from $17 | Refundable Tickets

Next bus departures

Next departures for Rome to Isernia on November 19
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	5:10am	Rome Tiburtina Bus Station	6h 14m	11:24am	Isernia	CheapestFastest
Bus	4:05am	Rome Fiumicino Airport	7h 19m	11:24am	Isernia	No tags
Bus	4:40am	Aeroporto Ciampino Airport (CIA)	6h 44m	11:24am	Isernia	No tags

Next departures for Rome to Isernia on November 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	2:45am	Rome Tiburtina Bus Station	8h 39m	11:24am	Isernia	CheapestFastest

Last refresh of the prices: Last Sunday at 4:09 PM CET.

Compare 3 ways to go from Rome to Isernia

We recommend carpooling

Among the sustainable travel choices, the carpool stands out as the good way to reach Isernia. The journey takes about 2 hours and with fares starting at just $9, it presents an excellent value for a comfortable ride.

4carpool per day

2hAverage Duration

93 milesDistance

6kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions
Bus	Average Price$21 - $66	Average Duration6h 44m	CO₂ emissions 3kg CO₂e
Train	Average Price$21 - $22	Average Duration2h 48m	CO₂ emissions 4kg CO₂e
Carpool	Average Price$9 - $21	Average Duration2h	CO₂ emissions 6kg CO₂e

Compare bus companies

FlixBus

3.5/511,360 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

IT bus companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Rede Expressos, Trenitalia

Where are the popular stops in Rome and Isernia?

Stops in Rome

A - Rome Tiburtina Bus Station

B - Rome Ciampino Airport

C - Rome Fiumicino Airport

D - Castro Pretorio

E - Roma

F - Anagnina

Stops in Isernia

A - Isernia

Frequently asked questions about traveling from Rome to Isernia by bus

How much does a bus ticket from Rome to Isernia cost?
How long is the bus ride from Rome to Isernia?
How many daily bus connections are there between Rome and Isernia?
Which bus companies travel from Rome to Isernia?
What are the departure and arrival stations when taking the bus from Rome to Isernia?

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11/16

$17

11/17

$24

Today

$17

11/19

$19

11/20

No data

11/21

$30

11/22

$25

11/23

$25

The cheapest trip from Rome to Isernia was searched and found on Nov 18, 2025 with a price of $17

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Rome to Isernia, as early as possible.

You can expect to pay from $17 to $57 for a bus ticket from Rome to Isernia based on the last 2 days. You can expect to find the cheapest price for the trip at $19 which is on 2025-11-19.