Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Penco | Terminal Sur | Cheapest | ||||
| Bus | Penco | Terminal Sur | Fastest | ||||
| Bus | Penco | Terminal Sur | No tags | ||||
| Bus | Penco | Terminal Sur | No tags | ||||
| Bus | Penco | Terminal Sur | No tags |
Last refresh of the prices: Last Wednesday at 8:16 AM -03.
Get from Penco to Santiago
The journey takes about 5 hours 6 minutes, and with fares starting at just R 261, it presents an excellent value for a comfortable ride.
Where are the popular stops in Penco and Santiago?
Stops in Penco
- A
Terminal de Autobuses de Penco
Ruta 150 9, Penco, Región del Bío Bío, Chile
Stops in Santiago
- ASantiago - Av Libertador Bernardo O'Higgins 3850, Santiago, Estación Central, Región Metropolitana, Chile
- B
San Borja
San Francisco de Borja 199-225, Santiago, Estación Central, Región Metropolitana, Chile - CTucapel Jiménez 21, 8340528 Santiago, Región Metropolitana, Chile
- DPdte. Riesco 6391-6399, Las Condes, Región Metropolitana, Chile
- EAv. Gral. Oscar Bonilla 418, Lo Prado, Región Metropolitana, Chile
- F
Zapadores
Los Zapadores 608, Recoleta, Región Metropolitana, Chile
Compare bus companies
Based on 157 reviews, the company was rated 3.8 stars on Busbud. Travellers were especially satisfied with the cleanliness and the ticket access but often complained with the Wi-Fi. Eme Bus ticket prices on this trip start at R 261
Frequently asked questions about travelling from Penco to Santiago, CL by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Penco to Santiago?
The cheapest bus tickets from Penco to Santiago start at R 261. The average price for this route is around R 407. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Penco to Santiago?
The average bus journey time from Penco to Santiago is 5h 6m, covering a distance of 421 km. The fastest bus gets you there in 5h 6m and is operated by Eme Bus.
Which bus companies service the Penco to Santiago route?
Several major bus companies operate on this route with 5 buses available per day.
What is the earliest and latest departure time for the bus from Penco to Santiago?
The earliest bus departs from Penco to Santiago at 00:19. And the latest bus departs at 23:05.
What are the CO₂ emissions for the bus trip from Penco to Santiago?
A bus trip from Penco to Santiago produces an estimated 11 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Penco to Santiago, CL was searched and found on 27 Dec 2025 with a price of R 243To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Penco to Santiago, CL as early as possible.
You can expect to pay from R 243 to R 447 for a bus ticket from Penco to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at R 244, which is on 2025-12-28.
