Bus from La Crosse, WI to Milwaukee: Tickets & Timetables

Next bus departures

Next departures from La Crosse to Milwaukee on 26 December
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Jefferson LinesBus
    		314 Jay St., La Crosse
    		St. Paul & N5thCheapest
    Jefferson LinesBus
      		La Crosse (U of WI)
      		St. Paul & N5thFastest
      Megabus USBus
        		La Crosse St Andrew St
        		Milwaukee Bus Station, St. Paul & N6th road.No tags
        Megabus USBus
          		La Crosse WI - University of Wisconsin (LSW)
          		Milwaukee Bus Station, St. Paul & N6th road.No tags

          Last refresh of the prices: Yesterday at 4:01 PM CST.

          Compare 2 ways to travel from La Crosse to Milwaukee

          We recommend taking the bus

          Among the sustainable travel choices, the bus stands out as a good way to reach Milwaukee. The journey takes about 3 hours 50 minutes and with fares starting at just R 687, it presents an excellent value for a comfortable ride.

          3bus per day
          3h 50mAverage duration
          282 kmDistance
          7kgCO₂ emissions
          Bus
          		Average priceR 687 - R 960Average duration3h 50m
          7kg CO₂e
          Train
          		Average priceR 446 - R 2 992Average duration3h 36m
          26kg CO₂e

          Frequently asked questions about travelling from La Crosse, WI to Milwaukee by bus

          Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.

          1. How much is the bus ticket from La Crosse to Milwaukee?

            The cheapest bus tickets from La Crosse to Milwaukee start at R 687. The average price for this route is around R 757. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.

          2. How long is the bus journey from La Crosse to Milwaukee?

            The average bus journey time from La Crosse to Milwaukee is 3h 50m, covering a distance of 282 km. The fastest bus gets you there in 3h 45m and is operated by Jefferson Lines.

          3. Which bus companies service the La Crosse to Milwaukee route?

            Several major bus companies operate on this route with 3 buses available per day, including services from Jefferson Lines, Megabus.

          4. What is the earliest and latest departure time for the bus from La Crosse to Milwaukee?

            The earliest bus departs from La Crosse to Milwaukee at 14:10. And the latest bus departs at 16:10.

          5. What are the CO₂ emissions for the bus trip from La Crosse to Milwaukee?

            A bus trip from La Crosse to Milwaukee produces an estimated 7 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.

          6. What is the best bus company from La Crosse to Milwaukee?

            According to Busbud customers, the highest-rated bus company on this route is Jefferson Lines, with an average rating of 3.9 out of 5 stars based on 759 reviews.

          7. Which bus company has the best Wi-Fi from La Crosse to Milwaukee?

            Based on reviews on Busbud, the bus company Jefferson Lines has the best Wi-Fi rating with a score of 3.1.

          8. Which bus company offers the most punctual service from La Crosse to Milwaukee?

            According to Busbud traveller reviews, the most punctual bus company on this route is Jefferson Lines, with a punctuality rating of 3.8 out of 5 stars.

          9. Which bus company has the cleanest buses from La Crosse to Milwaukee?

            According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Megabus, with a cleanliness rating of 4.3 out of 5 stars.

          Find cheapest prices for buses

          Price is for a one-way ticket for one passenger and based on past searches.

          Best price found
          23/12
          R 735
          24/12
          R 735
          Today
          R 667
          26/12
          R 735
          27/12
          R 735
          28/12
          R 735
          29/12
          R 735
          30/12
          R 667
          busbud logoThe cheapest trip from La Crosse, WI to Milwaukee was searched and found on 25 Dec 2025 with a price of R 667

          To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Milwaukee as early as possible.

          You can expect to pay from R 667 to R 923 for a bus ticket from La Crosse, WI to Milwaukee based on the last 2 days. You can expect to find the cheapest price for the trip at R 667, which is on 2025-12-30.

          What's the cheapest way to go from La Crosse, WI to Milwaukee?

          busbud logoThe bus is the cheapest travel choice for this destination

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