What is the distance between La Crosse and Milwaukee?

The distance between La Crosse and Milwaukee is approximately 284 km (176 miles).

Bus La Crosse to Milwaukee from $57 | Refundable Tickets

Next bus departures

Next departures for La Crosse to Milwaukee on November 24
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	2:30pm	La Crosse MTU Transit Center	3h 50m	6:20pm	St. Paul & N5th	Cheapest
Bus	2:35pm	632 17th Street North	3h 45m	6:20pm	St. Paul & N5th	Fastest
Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags
Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags

Next departures for La Crosse to Milwaukee on November 25
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	Cheapest
	Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	Fastest

Next departures for La Crosse to Milwaukee on November 26
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	2:30pm	La Crosse MTU Transit Center	3h 50m	6:20pm	St. Paul & N5th	Cheapest
Bus	2:35pm	632 17th Street North	3h 45m	6:20pm	St. Paul & N5th	Fastest
Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags
Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags

Next departures for La Crosse to Milwaukee on November 27
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	2:30pm	La Crosse MTU Transit Center	3h 50m	6:20pm	St. Paul & N5th	Cheapest
Bus	2:35pm	632 17th Street North	3h 45m	6:20pm	St. Paul & N5th	Fastest
Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags
Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags

Next departures for La Crosse to Milwaukee on November 28
Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Bus	2:30pm	La Crosse MTU Transit Center	3h 50m	6:20pm	St. Paul & N5th	Cheapest
Bus	2:35pm	632 17th Street North	3h 45m	6:20pm	St. Paul & N5th	Fastest
Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags
Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	No tags

Next departures for La Crosse to Milwaukee on November 29
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended	Price and booking link
	Bus	4:00pm	La Crosse St Andrew St	4h 50m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	Cheapest
	Bus	4:10pm	La Crosse WI - University of Wisconsin (LSW)	4h 40m	8:50pm	Milwaukee Bus Station, St. Paul & N6th road.	Fastest

Last refresh of the prices: Yesterday at 1:41 PM CST.

Compare 2 ways to go from La Crosse to Milwaukee

We recommend taking the train

Among the sustainable travel choices, the train stands out as a good way to reach Milwaukee. The journey takes about 3 hours 36 minutes, and with fares starting at just $38, it presents an excellent value for a comfortable ride.

4train per day

3h 36mAverage Duration

287 kmDistance

26kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$59 - $82	Average Duration4h 40m	CO₂ emissions 7kg CO₂e
Train	Average Price$38 - $327	Average Duration3h 36m	CO₂ emissions 26kg CO₂e

Compare bus companies

Megabus

3.5/5412 reviews

Staff4.1

Timeliness3.7

Cleanliness4.3

Wifi2.4

Jefferson Lines

4/5759 reviews

Staff4

Timeliness3.8

Cleanliness4

Wifi3.2

Based on 759 reviews, the company was rated 3.9 stars on Busbud. Travellers were especially satisfied with the temperature and the seats but often complained with the WiFi. Jefferson Lines ticket prices on this trip start at $59

Jefferson Lines La Crosse Milwaukee recent customer reviews

confusing instructions to where the bus would pick me up, made me miss my bus. awful return exchange policy, so i cant do anything about it

Kaitlyn S.

January 30, 2022

Amtrak

4/55,604 reviews

Staff4.7

Timeliness3.8

Cleanliness4.6

Wifi3.6

Based on 5604 reviews, the company was rated 4.1 stars on Busbud. Travellers were especially satisfied with the seats and the ticket access but often complained with the WiFi. Amtrak ticket prices on this trip start at $71

Amtrak La Crosse Milwaukee recent customer reviews

Very pleasant experience and very helpful staff.

Linda G.

May 20, 2025

It was nice

Eternity W.

May 30, 2024

US Bus Companies: FlixBus, BlaBlaCar Bus, ALSA, Greyhound, Intercape, Trenitalia, Sindbad

Frequently asked questions about travelling from La Crosse, WI to Milwaukee by bus

What is the distance between La Crosse and Milwaukee?
The distance between La Crosse and Milwaukee is approximately 284 km (176 miles).

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

11-22

$63

11-23

$63

Today

$63

11-25

$63

11-26

$63

11-27

$57

11-28

$63

11-29

$63

The cheapest trip from La Crosse, WI to Milwaukee was searched and found on Nov 27, 2025 with a price of $57

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Crosse, WI to Milwaukee, as early as possible.

You can expect to pay from $57 to $79 for a bus ticket from La Crosse, WI to Milwaukee based on the last 2 days. You can expect to find the cheapest price for the trip at $57 which is on 2025-11-27.

Usually Megabus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.