Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Louisville, KY | Gateway Station | Cheapest | |||||
 | Louisville, KY | Gateway Station | Fastest | |||||
 | Louisville, KY | Gateway Station | No tags | |||||
Greyhound Lines, Inc. + FlixBus | Louisville, KY | Gateway Station | No tags | |||||
| Louisville, KY | Gateway Station | No tags |
Last refresh of the prices: Yesterday at 03:10 EST.
Get from Louisville to St. Louis
The journey takes about 10 hours 50 minutes, and with fares starting at just £43, it presents an excellent value for a comfortable ride.
Where are the popular stops in Louisville and St. Louis?
Stops in Louisville
- A
Louisville Greyhound Bus Station
720 W Muhammad Ali Blvd, Louisville, KY 40203
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Frequently asked questions about travelling by bus from Louisville to St. Louis
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Louisville to St. Louis?
The cheapest coach tickets from Louisville to St. Louis start from £43. The average price for this route is around £72. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Louisville to St. Louis?
The average bus journey time from Louisville to St. Louis is 10h 50m, covering a distance of 241 miles. The fastest bus can take you there in 8h 20m and is operated by Greyhound.
Which bus companies service the Louisville to St. Louis route?
What is the earliest and latest departure time for the bus from Louisville to St. Louis?
The earliest bus departs from Louisville to St. Louis at 06:05. And the latest bus departs at 22:55.
What are the CO₂ emissions for the bus trip from Louisville to St. Louis?
A bus journey from Louisville to St. Louis produces an estimated 10 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Louisville to St. Louis?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5597 reviews.
Which company has the best Wi-Fi from Louisville to St. Louis?
Based on Busbud reviews, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company offers the most punctual service from Louisville to St. Louis?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Louisville to St. Louis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Louisville to St. Louis was searched and found on 5 Dec 2025 with a price of £50To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Louisville to St. Louis as early as possible.
You can expect to pay from £50 to £146 for a bus ticket from Louisville to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at £50, which is on 2025-12-05.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
