Find coaches from Indianapolis to Greenville, SC

Next bus departures

Next departures from Indianapolis to Greenville on 12 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
Bus
Indianapolis Bus Station
1116 Woodruff RdCheapest
Greyhound Lines, Inc.Bus
Indianapolis Bus Station
1116 Woodruff RdFastest
Greyhound Lines, Inc. + FlixBus
Bus
Indianapolis Bus Station
1116 Woodruff RdNo tags
FlixBusBus
Downtown Transit Center
1116 Woodruff RdNo tags
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Transit Center
1116 Woodruff RdNo tags

Last refresh of the prices: Yesterday at 03:23 EST.

Compare 2 ways to travel from Indianapolis to Greenville

We recommend taking the bus

Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 16 hours 15 minutes and with fares starting at just £54, it presents an excellent value for a comfortable ride.

6bus per day
16h 15mAverage duration
401 milesDistance
16kgCO₂ emissions
Bus
Average price£54 - £148Average duration16h 15m
16kg CO₂e
Train
Average price£122 - £1,133Average duration1d 5h
58kg CO₂e

Frequently asked questions about travelling by bus from Indianapolis to Greenville, SC

  1. What's the distance between Indianapolis and Greenville by coach?

    The distance between Indianapolis and Greenville by coach is approximately 398 miles (641 km).

  2. What is the best way to go from Indianapolis to Greenville without flying?

    You have the option to select the coach for your journey on this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
09/11
£106
10/11
£109
Today
£99
12/11
£73
13/11
No data
14/11
£68
15/11
No data
16/11
£65
busbud logoThe cheapest trip from Indianapolis to Greenville, SC was searched and found on 16 Nov 2025 with a price of £65

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Greenville, SC as early as possible.

You can expect to pay from £65 to £125 for a bus ticket from Indianapolis to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at £65, which is on 2025-11-16.

Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

What's the cheapest way to go from Indianapolis to Greenville, SC?

busbud logoThe bus is the cheapest travel choice for this destination

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