Bus Tickets from Indianapolis to Greenville, SC

Next departures

Next departures for Indianapolis to Greenville on November 7
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
Greyhound Lines, Inc. + FlixBus
    		Indianapolis Bus Station
    		1116 Woodruff RdCheapest
    Greyhound Lines, Inc.
      		Indianapolis Bus Station
      		1116 Woodruff RdFastest
      FlixBus + Greyhound Lines, Inc.
        		Downtown Transit Center
        		1116 Woodruff RdNo tags
        FlixBus
          		Downtown Transit Center
          		1116 Woodruff RdNo tags

          Last refresh of the prices: Yesterday at 3:46 PM EST.

          Compare 2 ways to go from Indianapolis to Greenville

          We recommend taking the bus

          Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 16 hours 15 minutes, and with fares starting at just $101, it presents an excellent value for a comfortable ride.

          6bus per day
          16h 15mAverage Duration
          646 kmDistance
          16kgCO₂ emissions
          Bus
          		Average Price$101 - $274Average Duration16h 15m
          16kg CO₂e
          Train
          		Average Price$225 - $2,099Average Duration1d 5h
          58kg CO₂e

          Frequently asked questions about travelling from Indianapolis to Greenville, SC by bus

          1. What is the distance between Indianapolis and Greenville?

            The distance covered from Indianapolis to Greenville is 641 km (398 miles).

          2. What are the departure and arrival locations for buses traveling from Indianapolis to Greenville?

            Buses traveling this route start their trip at Greyhound Amtrak Station, in Indianapolis, and end it at Guadalajara Supermarket Bus Stop, in Greenville.

          Find cheapest prices for buses

          Price is for a one-way ticket for one passenger and based on past searches.

          Best price found
          11-05
          $165
          11-06
          No data
          Today
          $168
          11-08
          No data
          11-09
          $126
          11-10
          No data
          11-11
          No data
          11-12
          No data
          busbud logoThe cheapest trip from Indianapolis to Greenville, SC was searched and found on Nov 9, 2025 with a price of $126

          To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Indianapolis to Greenville, SC, as early as possible.

          You can expect to pay from $126 to $278 for a bus ticket from Indianapolis to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at $126 which is on 2025-11-09.

          Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

          What's the cheapest way to go from Indianapolis to Greenville, SC?

          busbud logoThe bus is the cheapest travel choice for this destination

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