Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Tampa Bus Station | Port St. Lucie (Park & Ride) | Cheapest | ||||
 | Bus | Tampa Bus Station | Port St. Lucie (Park & Ride) | Fastest | ||||
| Bus | University of South Florida | Port St. Lucie (Park & Ride) | No tags |
Last refresh of the prices: Yesterday at 7:03 PM EST.
Get from Tampa to Port Saint Lucie
The journey takes about 5 hours 25 minutes, and with fares starting at just $56, it presents an excellent value for a comfortable ride.
Where are the popular stops in Tampa and Port Saint Lucie?
Stops in Tampa
- A
Tampa 13th Avenue Bus Stop (McDonald's)
2101 E 13th Ave (McDonald's), Tampa, FL 33605 - B
Tampa USF, FL
3801 USF Holly Drive, Tampa., FL 33620, USA - C
Greyhound Station
610 E Polk St, Tampa, FL 33602, USA - D
E Sligh Ave
11555 E Sligh Ave, Seffner, FL 33584, USA - E
N Marion St & E Laurel St
551 E Laurel St, Tampa, FL 33602, USA - F
Port of Tampa
200-298 FL-60, Tampa, FL 33602, USA
Stops in Port Saint Lucie
- A
Port St Lucie Mobil Gas Bus Stop
1820 Sw Fountainview Blvd, Port Saint Lucie, FL 34986 - B
Port Saint Lucie - Wendys
1790 SW St Lucie W Blvd, Port St Lucie, FL 34986 - C
Port Saint LucieService Plaza
Florida's Turnpike, Milepost 144, Port St Lucie, FL 34984, USA - D
Port Saint Lucie Bus Stop
2198 SW Gatlin Blvd. Port St. Lucie, FL 34953
Compare bus companies
Frequently asked questions about travelling from Tampa to Port Saint Lucie by bus
What is the travel distance from Tampa to Port Saint Lucie?
It's about 221 km (137 miles) from Tampa to Port Saint Lucie.
What are the departure and arrival locations for buses traveling from Tampa to Port Saint Lucie?
Buses departing from Tampa 13th Avenue Bus Stop (McDonald's) in Tampa will take you to Port St Lucie Mobil Gas Bus Stop in Port Saint Lucie.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tampa to Port Saint Lucie was searched and found on Nov 27, 2025 with a price of $70To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tampa to Port Saint Lucie, as early as possible.
You can expect to pay from $70 to $149 for a bus ticket from Tampa to Port Saint Lucie based on the last 2 days. You can expect to find the cheapest price for the trip at $70 which is on 2025-11-27.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
