Previously seen trips
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Port St Lucie (Park & Ride) | Jacksonville Bus Station | No tags | ||||
 | Bus | Port St Lucie (Park & Ride) | Jacksonville Bus Station | No tags | ||||
| Bus | Port St Lucie (Park & Ride) | Jacksonville Bus Station | No tags | ||||
| Bus | Port St Lucie (Park & Ride) | Jacksonville Bus Station | No tags | ||||
| Bus | Port St Lucie (Park & Ride) | Jacksonville Bus Station | No tags |
Get from Port Saint Lucie to Jacksonville
The journey takes about 6 hours 5 minutes, and with fares starting at just $57, it presents an excellent value for a comfortable ride.
Where are the popular stops in Port Saint Lucie and Jacksonville?
Stops in Port Saint Lucie
- A
Port St Lucie Mobil Gas Bus Stop
1820 Sw Fountainview Blvd, Port Saint Lucie, FL 34986 - B
Port Saint Lucie - Wendys
1790 SW St Lucie W Blvd, Port St Lucie, FL 34986 - C
Port Saint LucieService Plaza
Florida's Turnpike, Milepost 144, Port St Lucie, FL 34984, USA - D
Port Saint Lucie Bus Stop
2198 SW Gatlin Blvd. Port St. Lucie, FL 34953
Stops in Jacksonville
- A3570 Clifford Ln, Jacksonville, FL 32209, USA
- B
W Forsyth St
1111 W Forsyth St, Jacksonville, FL 32204, USA - C
Kings Avenue Station
1003 Kings Avenue, Jacksonville, FL 32207 - D
JRTC Greyhound Bus Station
111 W. Forsyth St, Jacksonville, FL 32202, USA
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Frequently asked questions about travelling from Port Saint Lucie to Jacksonville, FL by bus
What is the travel distance from Port Saint Lucie to Jacksonville?
The distance covered from Port Saint Lucie to Jacksonville is 362 km (225 miles).
What are the departure and arrival locations for buses traveling from Port Saint Lucie to Jacksonville?
Buses traveling this route start their trip at Port St Lucie Mobil Gas Bus Stop, in Port Saint Lucie, and end it at Jacksonville Amtrak Station, in Jacksonville.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Port Saint Lucie to Jacksonville, FL was searched and found on Nov 19, 2025 with a price of $60To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Port Saint Lucie to Jacksonville, FL, as early as possible.
You can expect to pay from $60 to $129 for a bus ticket from Port Saint Lucie to Jacksonville, FL based on the last 2 days. You can expect to find the cheapest price for the trip at $66 which is on 2025-11-22.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
Top travelled bus routes
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Popular bus departures from Port Saint Lucie
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