Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Gasolinera Puma Los Naranjos | Hotel las Americas | Cheapest | ||||
| Bus | Gasolinera Puma Los Naranjos | Metroplaza Guatemala | Fastest | ||||
| Bus | Gasolinera Puma Los Naranjos | Hotel las Americas | No tags | ||||
 | Bus | Gasolinera Puma | Holiday Inn Guatemala City | No tags | ||||
| Bus | Gasolinera Puma Los Naranjos | Hotel las Americas | No tags |
Last refresh of the prices: Last Saturday at 8:00 AM CST.
Get from Santa Ana to Guatemala City
The journey takes about 4 hours, and with fares starting at just $51, it presents an excellent value for a comfortable ride.
Compare bus companies
Frequently asked questions about travelling from Santa Ana, SV to Guatemala City by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Santa Ana to Guatemala City?
The cheapest bus tickets from Santa Ana to Guatemala City start from $51. The average price for this route is around $51. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Santa Ana to Guatemala City?
The average bus travel time from Santa Ana to Guatemala City is 4h, covering a distance of 122 km. The quickest bus can get you there in 4h and is operated by Transporte del Sol.
Which bus companies service the Santa Ana to Guatemala City route?
Several major bus companies operate on this route with 7 buses available per day, including services from Transporte del Sol, Guatego.
What are the earliest and latest departure times for the bus from Santa Ana to Guatemala City?
The earliest bus departs from Santa Ana to Guatemala City at 6:00am. And the latest bus departs at 7:15pm.
What are the CO₂ emissions for the bus trip from Santa Ana to Guatemala City?
A bus trip from Santa Ana to Guatemala City generates an estimated 3 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Santa Ana to Guatemala City?
According to Busbud customers, the highest-rated bus company on this route is Transporte del Sol, with an average rating of 3.3 out of 5 stars based on 27 reviews.
Which bus company has the best Wi-Fi from Santa Ana to Guatemala City?
Based on Busbud reviews, the bus company Guatego has the highest Wi-Fi rating with a score of 2.5.
Which bus company has the best on-time performance from Santa Ana to Guatemala City?
According to Busbud traveller reviews, the most punctual bus company on this route is Guatego, with a punctuality rating of 4.0 out of 5 stars.
Which bus company has the cleanest buses from Santa Ana to Guatemala City?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Guatego, with a cleanliness rating of 5.0 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santa Ana, SV to Guatemala City was searched and found on Nov 29, 2025 with a price of $51To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Ana, SV to Guatemala City, as early as possible.
You can expect to pay from $51 to $127 for a bus ticket from Santa Ana, SV to Guatemala City based on the last 2 days. You can expect to find the cheapest price for the trip at $51 which is on 2025-12-02.
Usually Guatego will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
