Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Gasolinera Puma Los Naranjos | Hotel las Americas | Cheapest | ||||
| Bus | Gasolinera Puma Los Naranjos | Metroplaza Guatemala | Fastest | ||||
| Bus | Gasolinera Puma Los Naranjos | Hotel las Americas | No tags | ||||
| Bus | Gasolinera Puma Los Naranjos | Metroplaza Guatemala | No tags |
Last refresh of the prices: Yesterday at 8:46 AM CST.
Get from Santa Ana to Guatemala City
The journey takes about 4 hours, and with fares starting at just R 619, it presents an excellent value for a comfortable ride.
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Frequently asked questions about travelling from Santa Ana, SV to Guatemala City by bus
How much does a bus ticket from Santa Ana to Guatemala City cost?
The bus ticket price from Santa Ana to Guatemala City starts at R 619. The best way to find cheap bus tickets from Santa Ana to Guatemala City is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Santa Ana to Guatemala City?
The average travel time between Santa Ana and Guatemala City is around 4h, although the fastest bus will take about 4h. This is the time it takes to travel the 126 km that separates the two cities.
How many daily bus connections are there between Santa Ana and Guatemala City?
The number of buses from Santa Ana to Guatemala City can differ depending on the day of the week. On average, there are 7 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Santa Ana to Guatemala City by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Santa Ana to Guatemala City?
When taking the bus from Santa Ana to Guatemala City, you can travel comfortably and safely with Transporte del Sol, Guatego.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Santa Ana, SV to Guatemala City was searched and found on 23 Nov 2025 with a price of R 619To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santa Ana, SV to Guatemala City as early as possible.
You can expect to pay from R 619 to R 1 557 for a bus ticket from Santa Ana, SV to Guatemala City based on the last 2 days. You can expect to find the cheapest price for the trip at R 619, which is on 2025-11-27.
Usually Guatego will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.