How much is the bus ticket from San Ysidro to Boston?

The cheapest bus tickets from San Ysidro to Boston start from $325. The average price for this route is around $410. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from San Ysidro to Boston?

The average bus travel time from San Ysidro to Boston is 3d 7h, covering a distance of 4149 km. The quickest bus can get you there in 3d 7h and is operated by Greyhound .

Which bus companies service the San Ysidro to Boston route?

Several major bus companies operate on this route with 6 buses available per day.

What are the earliest and latest departure times for the bus from San Ysidro to Boston?

The earliest bus departs from San Ysidro to Boston at 6:55am. And the latest bus departs at 7:00pm.

What are the CO₂ emissions for the bus trip from San Ysidro to Boston?

A bus trip from San Ysidro to Boston generates an estimated 104 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

Bus San Ysidro to Boston from $322 | Refundable Tickets

Next bus departures

Next departures for San Ysidro to Boston on December 28
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	1:15pm	San Ysidro Bus terminal	3d 5h	9:50pm	Boston (South Station)	CheapestFastest
	Bus	7:00pm	San Ysidro Bus terminal	3d 7h	5:10am	Boston (South Station)	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:00pm	San Ysidro Bus terminal	3d 11h	9:00am	Brookline	No tags

Next departures for San Ysidro to Boston on December 29
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	1:15pm	San Ysidro Bus terminal	3d 5h	9:45pm	151 Steel Pl, Cambridge	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	9:25am	San Ysidro Bus terminal	3d 2h	3:10pm	Boston (South Station)	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	1:15pm	San Ysidro Bus terminal	3d 5h	9:50pm	Boston (South Station)	No tags
	Bus	7:00pm	San Ysidro Bus terminal	3d 7h	5:10am	Boston (South Station)	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:00pm	San Ysidro Bus terminal	3d 7h	5:40am	Brookline	No tags

Next departures for San Ysidro to Boston on December 30
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	1:15pm	San Ysidro Bus terminal	3d 5h	9:50pm	Boston (South Station)	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	6:55am	San Ysidro Bus terminal	3d 5h	3:10pm	Boston (South Station)	Fastest
	Bus	7:00pm	San Ysidro Bus terminal	3d 7h	5:10am	Boston (South Station)	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:00pm	San Ysidro Bus terminal	3d 7h	5:40am	Brookline	No tags
FlixBus + Greyhound Lines, Inc.	Bus	6:55am	San Ysidro Bus terminal	3d 9h	7:20pm	151 Steel Pl, Cambridge	No tags

Next departures for San Ysidro to Boston on December 31
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	6:55am	San Ysidro Bus terminal	3d 9h	7:20pm	151 Steel Pl, Cambridge	Cheapest
FlixBus + Greyhound Lines, Inc.	Bus	6:55am	San Ysidro Bus terminal	3d 5h	3:10pm	Boston (South Station)	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	1:15pm	San Ysidro Bus terminal	3d 5h	9:50pm	Boston (South Station)	No tags
	Bus	7:00pm	San Ysidro Bus terminal	3d 7h	5:10am	Boston (South Station)	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:00pm	San Ysidro Bus terminal	3d 7h	5:40am	Brookline	No tags

Next departures for San Ysidro to Boston on January 1
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
FlixBus + Greyhound Lines, Inc.	Bus	1:15pm	San Ysidro Bus terminal	3d 5h	9:50pm	Boston (South Station)	Cheapest
Greyhound Lines, Inc. + FlixBus	Bus	9:25am	San Ysidro Bus terminal	3d 2h	3:10pm	Boston (South Station)	Fastest
	Bus	7:00pm	San Ysidro Bus terminal	3d 7h	5:10am	Boston (South Station)	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:00pm	San Ysidro Bus terminal	3d 7h	5:40am	Brookline	No tags
Greyhound Lines, Inc. + FlixBus	Bus	9:25am	San Ysidro Bus terminal	3d 6h	7:20pm	151 Steel Pl, Cambridge	No tags

Next departures for San Ysidro to Boston on January 2
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	9:25am	San Ysidro Bus terminal	3d 2h	3:10pm	Boston (South Station)	CheapestFastest
FlixBus + Greyhound Lines, Inc.	Bus	1:15pm	San Ysidro Bus terminal	3d 5h	9:50pm	Boston (South Station)	No tags
	Bus	7:00pm	San Ysidro Bus terminal	3d 7h	5:10am	Boston (South Station)	No tags
Greyhound Lines, Inc. + FlixBus	Bus	9:25am	San Ysidro Bus terminal	3d 17h	5:40am	Brookline	No tags
Greyhound Lines, Inc. + FlixBus	Bus	7:00pm	San Ysidro Bus terminal	3d 9h	7:20am	Brookline	No tags

Last refresh of the prices: Yesterday at 1:49 PM PST.

Get from San Ysidro to Boston

This route is served by bus only

The journey takes about 3 days, 7 hours 10 minutes, and with fares starting at just $325, it presents an excellent value for a comfortable ride.

6bus per day

3d 7hAverage Duration

4149 kmDistance

104kgCO₂ emissions

Where are the popular stops in San Ysidro and Boston?

Stops in San Ysidro

A
San Ysidro Greyhound Bus Station
731 E San Ysidro Blvd, San Ysidro, CA 92173
Visit page

Stops in Boston

A
Back Bay Station
145 Dartmouth St, Boston, MA 02116, USA
Visit page
B
North Station
100 Legends Way, Boston, MA 02114, USA
Visit page
C
Copley Square
115-127 St James Ave, Boston, MA 02116, USA
D
Prudential MBTA Station
220 Huntington Ave, Boston, MA 02115, USA
E
Copley MBTA Station
650 Boylston St, Boston, MA 02116, USA
F
Long Wharf
66 Long Wharf, Boston, MA 02110, USA

Compare bus companies

Greyhound

3.5/587,456 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Based on 87456 reviews, the company was rated 3.5 stars on Busbud. Travellers were especially satisfied with the ticket access and the temperature but often complained with the WiFi. Greyhound ticket prices on this trip start at $325

US Bus Companies: FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about travelling from San Ysidro, CA to Boston, MA, US by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from San Ysidro to Boston?
The cheapest bus tickets from San Ysidro to Boston start from $325. The average price for this route is around $410. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Ysidro to Boston?
The average bus travel time from San Ysidro to Boston is 3d 7h, covering a distance of 4149 km. The quickest bus can get you there in 3d 7h and is operated by Greyhound.
Which bus companies service the San Ysidro to Boston route?
Several major bus companies operate on this route with 6 buses available per day.
What are the earliest and latest departure times for the bus from San Ysidro to Boston?
The earliest bus departs from San Ysidro to Boston at 6:55am. And the latest bus departs at 7:00pm.
What are the CO₂ emissions for the bus trip from San Ysidro to Boston?
A bus trip from San Ysidro to Boston generates an estimated 104 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12-26

$517

12-27

$395

Today

$371

12-29

$322

12-30

$366

12-31

$344

The cheapest trip from San Ysidro, CA to Boston, MA, US was searched and found on Dec 29, 2025 with a price of $322

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Ysidro, CA to Boston, MA, US, as early as possible.

You can expect to pay from $322 to $517 for a bus ticket from San Ysidro, CA to Boston, MA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $322 which is on 2025-12-29.