Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Harrisburg Bus Station | Downtown Greyhound Station | Cheapest | ||||
 | Bus | Harrisburg Bus Station | Downtown Greyhound Station | Fastest | ||||
| Bus | Harrisburg Bus Station | Downtown Greyhound Station | No tags | ||||
| Bus | Harrisburg Bus Station | Chicago 95Th & Dan Ryan | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Harrisburg Bus Station | Chicago 95Th & Dan Ryan | No tags |
Last refresh of the prices: Yesterday at 2:30 PM EST.
Compare 2 ways to go from Harrisburg to Chicago
Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 18 hours 10 minutes, and with fares starting at just $98, it presents an excellent value for a comfortable ride.
Where are the popular stops in Harrisburg and Chicago?
Stops in Harrisburg
- A
Harrisburg Bieber Greyhound Station
411 Market St, Harrisburg, PA 17101
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
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Frequently asked questions about travelling from Harrisburg to Chicago by bus
What is the travel distance from Harrisburg to Chicago?
The distance between Harrisburg and Chicago is approximately 920 km (571 miles).
What are the departure and arrival locations for buses traveling from Harrisburg to Chicago?
Buses departing from Harrisburg Bieber Greyhound Station in Harrisburg will take you to Downtown Greyhound Station in Chicago.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Harrisburg to Chicago was searched and found on Nov 27, 2025 with a price of $150To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Harrisburg to Chicago, as early as possible.
You can expect to pay from $150 to $442 for a bus ticket from Harrisburg to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $150 which is on 2025-11-27.
Usually Greyhound, FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Harrisburg to Chicago?
The bus is the cheapest travel choice for this destination
