Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Harrisburg Bus Station | Downtown Greyhound Station | Cheapest | ||||
 | Bus | Harrisburg Bus Station | Downtown Greyhound Station | Fastest | ||||
| Bus | Harrisburg Bus Station | Downtown Greyhound Station | No tags | ||||
| Bus | Harrisburg Bus Station | Chicago 95Th & Dan Ryan | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Harrisburg Bus Station | Chicago 95Th & Dan Ryan | No tags |
Last refresh of the prices: Yesterday at 14:30 EST.
Compare 2 ways to travel from Harrisburg to Chicago
Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 18 hours 10 minutes and with fares starting at just £53, it presents an excellent value for a comfortable ride.
Where are the popular stops in Harrisburg and Chicago?
Stops in Harrisburg
- A
Harrisburg Bieber Greyhound Station
411 Market St, Harrisburg, PA 17101
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Frequently asked questions about travelling by bus from Harrisburg to Chicago
How far is Chicago from Harrisburg by coach?
The journey from Harrisburg to Chicago by coach covers an approximate distance of 571 miles (920 km).
Is there a way to reach Chicago from Harrisburg without flying?
You can choose the coach to travel this route. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Harrisburg to Chicago was searched and found on 27 Nov 2025 with a price of £81To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Harrisburg to Chicago as early as possible.
You can expect to pay from £81 to £238 for a bus ticket from Harrisburg to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at £81, which is on 2025-11-27.
Usually Greyhound, FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Harrisburg to Chicago?
The bus is the cheapest travel choice for this destination
