Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | 1116 Woodruff Rd | Winston Salem Greyhound Bus Station | Cheapest | ||||
 | Bus | Greenville, (SC - Taqueria Guadalajara #3) | Winston-salem, (NC - Tienda Mexican El Crystal) | Fastest | ||||
 | Bus | Greenville, (SC - Taqueria Guadalajara #3) | Winston-salem, (NC - Tienda Mexican El Crystal) | No tags |
Last refresh of the prices: Last Friday at 8:13 AM EST.
Get from Greenville to Winston-Salem
The journey takes about 3 hours 10 minutes, and with fares starting at just $47, it presents an excellent value for a comfortable ride.
Where are the popular stops in Greenville and Winston-Salem?
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
Stops in Winston-Salem
- A
Winston Salem Greyhound Bus Station
100 W 5th St, Winston Salem, NC 27101 - B
E Sprague St
841 E Sprague St, Winston-Salem, NC 27107, USA - C
Winston-Salem Bus Stop
2500 Old Lexington Rd, Winston-Salem, NC 27107, USA - D
1237 Silas Creek Pkwy
1237 Silas Creek Pkwy., Winston-Salem, NC 27127 (Hong Kong King Buffet)
Compare bus companies
Frequently asked questions about travelling from Greenville, SC to Winston-Salem by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Greenville to Winston-Salem?
The cheapest bus tickets from Greenville to Winston-Salem start from $47. The average price for this route is around $216. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Greenville to Winston-Salem?
The average bus travel time from Greenville to Winston-Salem is 3h 10m, covering a distance of 242 km. The quickest bus can get you there in 3h 5m and is operated by Tornado Bus.
Which bus companies service the Greenville to Winston-Salem route?
Several major bus companies operate on this route with 3 buses available per day, including services from Tornado Bus, Greyhound.
What are the earliest and latest departure times for the bus from Greenville to Winston-Salem?
The earliest bus departs from Greenville to Winston-Salem at 10:50am. And the latest bus departs at 10:00pm.
What are the CO₂ emissions for the bus trip from Greenville to Winston-Salem?
A bus trip from Greenville to Winston-Salem generates an estimated 6 kg of CO₂, making it a highly eco-friendly travel option and a mode of travel recommended by Busbud.
What is the best bus company from Greenville to Winston-Salem?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87500 reviews.
Which bus company has the best Wi-Fi from Greenville to Winston-Salem?
Based on Busbud reviews, the bus company Tornado Bus has the highest Wi-Fi rating with a score of 4.1.
Which bus company has the best on-time performance from Greenville to Winston-Salem?
According to Busbud traveller reviews, the most punctual bus company on this route is Tornado Bus, with a punctuality rating of 3.4 out of 5 stars.
Which bus company has the cleanest buses from Greenville to Winston-Salem?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Tornado Bus, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Greenville, SC to Winston-Salem was searched and found on Jan 22, 2026 with a price of $39To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Greenville, SC to Winston-Salem, as early as possible.
You can expect to pay from $39 to $206 for a bus ticket from Greenville, SC to Winston-Salem based on the last 2 days. You can expect to find the cheapest price for the trip at $39 which is on 2026-01-22.
