Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Durham Greyhound Bus Station | Chicago 95Th & Dan Ryan | CheapestFastest | ||||
| Bus | Durham Greyhound Bus Station | Downtown Greyhound Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Durham Greyhound Bus Station | Downtown Greyhound Station | No tags | ||||
 | Bus | Durham Greyhound Bus Station | 537-517 W. Jackson Blvd | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Durham Greyhound Bus Station | Downtown Greyhound Station | No tags |
Last refresh of the prices: Last Tuesday at 8:59 PM EST.
Compare 2 ways to go from Durham to Chicago
Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 1 day, 1 hour 55 minutes, and with fares starting at just $122, it presents an excellent value for a comfortable ride.
Where are the popular stops in Durham and Chicago?
Stops in Durham
- A515 W Pettigrew St , Durham, NC 27703
- B
Compare Foods Durham
2000-2004 NC-55, Durham, NC 27704, USA - C
Durham Compare Foods Durham
2000 Avondale Dr, Durham, NC 27704, USA - D
Durham, NC
E Main St at Roxboro St (WB), Durham, NC 27701, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Frequently asked questions about travelling from Durham, NC, US to Chicago by bus
How far is Durham from Chicago?
The distance between Durham and Chicago is around 999 km (620 miles).
What are the departure and arrival locations for buses traveling from Durham to Chicago?
Buses traveling this route start their trip at Durham Greyhound Bus Station, in Durham, and end it at Downtown Greyhound Station, in Chicago.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Durham, NC, US to Chicago was searched and found on Nov 27, 2025 with a price of $186To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Durham, NC, US to Chicago, as early as possible.
You can expect to pay from $186 to $612 for a bus ticket from Durham, NC, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $186 which is on 2025-11-27.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Durham, NC, US to Chicago?
The bus is the cheapest travel choice for this destination
