Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | Bus | Durham Greyhound Bus Station | Chicago 95Th & Dan Ryan | Cheapest | ||||
 | Bus | Durham Greyhound Bus Station | Chicago 95Th & Dan Ryan | Fastest | ||||
| Bus | Durham Greyhound Bus Station | Downtown Greyhound Station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Durham Greyhound Bus Station | Downtown Greyhound Station | No tags | ||||
 | Bus | Durham Greyhound Bus Station | 537-517 W. Jackson Blvd | No tags |
Last refresh of the prices: 18/11/2025 EST.
Compare 2 ways to travel from Durham to Chicago
Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 1 day, 1 hour 55 minutes and with fares starting at just £66, it presents an excellent value for a comfortable ride.
Where are the popular stops in Durham and Chicago?
Stops in Durham
- A515 W Pettigrew St , Durham, NC 27703
- B
Compare Foods Durham
2000-2004 NC-55, Durham, NC 27704, USA - C
Durham Compare Foods Durham
2000 Avondale Dr, Durham, NC 27704, USA - D
Durham, NC
E Main St at Roxboro St (WB), Durham, NC 27701, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Frequently asked questions about travelling by bus from Durham, NC, US to Chicago
What's the distance between Durham and Chicago by coach?
The distance between Durham and Chicago by coach is approximately 620 miles (999 km).
How can I travel from Durham to Chicago avoiding air travel?
You have the option to select the coach for your journey on this route. The coach ensures a pleasant travel experience, granting you the opportunity to appreciate the scenery as you make your way to your final stop. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Durham, NC, US to Chicago was searched and found on 27 Nov 2025 with a price of £101To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Durham, NC, US to Chicago as early as possible.
You can expect to pay from £101 to £331 for a bus ticket from Durham, NC, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at £101, which is on 2025-11-27.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Durham, NC, US to Chicago?
The bus is the cheapest travel choice for this destination
