Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Columbus (E Mound St) | Gateway Station | Cheapest | ||||
| Bus | Columbus (E Mound St) | Gateway Station | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | 100 E Rich St | Gateway Station | No tags | ||||
 | Bus | 100 E Rich St | Gateway Station | No tags | ||||
| Bus | Columbus (E Mound St) | Gateway Station | No tags |
Last refresh of the prices: Today at 1:45 AM EST.
Get from Columbus to St. Louis
The journey takes about 11 hours 30 minutes, and with fares starting at just $73, it presents an excellent value for a comfortable ride.
Where are the popular stops in Columbus and St. Louis?
Stops in Columbus
- A
Columbus Bus Station
25 E Rich St, Columbus, OH 43205, USA
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Frequently asked questions about travelling from Columbus, OH to St. Louis by bus
How far is Columbus from St. Louis?
The distance between Columbus and St. Louis is around 638 km (396 miles).
What are the departure and arrival locations for buses traveling from Columbus to St. Louis?
Buses traveling this route start their trip at Columbus Bus Station, in Columbus, and end it at Gateway Station, in St. Louis.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Columbus, OH to St. Louis was searched and found on Dec 1, 2025 with a price of $80To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Columbus, OH to St. Louis, as early as possible.
You can expect to pay from $80 to $283 for a bus ticket from Columbus, OH to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at $80 which is on 2025-12-01.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
