Next departures for Syracuse to Detroit on November 19
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Greyhound + FlixBus
Bus
Syracuse (Regional Transportation Center)
Detroit Bus Station
No tags
Greyhound + FlixBus
Bus
Syracuse (Regional Transportation Center)
Detroit Bus Station
No tags
Bus
SYR Airport
Indian Trails Bus Terminal
No tags
Bus
SYR Airport
Indian Trails Bus Terminal
No tags
Bus
Syracuse University
Indian Trails Bus Terminal
No tags
Compare 2 ways to go from Syracuse to Detroit
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach Detroit. The journey takes about 11 hours 15 minutes and with fares starting at just $79, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Trailways is a network of over 70 bus companies that focus on providing quality bus rides at affordable prices all over the US since 1936. Among the most famous affiliates are Trailways of New York, Pine Hill Trailways, Adirondack Trailways and Burlington Trailways. Trailways buses have WiFi, power outlets, bathrooms, air conditioning, overhead lighting, and reclinable seats with footrests. You can find two different types of Trailway fares: saver and flexible. Saver tickets are non-refundable, while flexible tickets are fully reimbursed up to one hour before travel time. If you're traveling with them, don't forget to print your boarding pass and show a valid photo ID to board the bus.
Based on 1126 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the ticket access and the cleanliness but often complained with the wifi. Adirondack Trailways ticket prices on this trip start at $295
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Bus stops at Schine Student Center across the street from the Sheraton Parking Garage., Schine Student Center, 303 University Pl, Syracuse, NY 13210Syracuse University
Frequently asked questions about traveling from Syracuse, US to Detroit, MI by bus
What is the travel distance from Syracuse to Detroit?
Syracuse and Detroit are 354 miles (570 km) apart.
What are the departure and arrival stations when taking the bus from Syracuse to Detroit?
The majority of buses traveling from Syracuse to Detroit start their journey at Regional Transportation Center and wind up at Detroit Bus Station. These are the most popular pick-up and drop-off locations on this route, there are other pick-up and drop-off locations that could make it easier for you to reach your destination.
What are the best sights and things to do in Detroit?
Once in Detroit, you can start exploring the city and discover its surroundings. The top sights and things to do are Henry Ford Museum, Mexicantown, Ford Field, Ford Piquette Avenue Plant and Old St. Mary.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/16
$72
11/17
No data
Today
No data
11/19
No data
11/20
No data
11/21
No data
11/22
No data
11/23
$61
The cheapest trip from Syracuse, US to Detroit, MI was searched and found on Nov 23, 2025 with a price of $61
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Syracuse, US to Detroit, MI, as early as possible.
You can expect to pay from $61 to $72 for a bus ticket from Syracuse, US to Detroit, MI based on the last 2 days. You can expect to find the cheapest price for the trip at $61 which is on 2025-11-23.
What's the cheapest way to go from Syracuse, US to Detroit, MI?
The bus is the cheapest travel choice for this destination