Next departures for Santander to Madrid on November 18
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Santander (Estacion de Autobuses)
Avenida de América Metro
Cheapest
Bus
Santander (Estacion de Autobuses)
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
Fastest
Bus
Santander (Estacion de Autobuses)
Avenida de América Metro
No tags
Bus
Santander (Estacion de Autobuses)
Madrid (South)
No tags
Bus
Santander (Estacion de Autobuses)
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
No tags
Next departures for Santander to Madrid on November 19
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Santander (Estacion de Autobuses)
Avenida de América Metro
Cheapest
Bus
Santander (Estacion de Autobuses)
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
Fastest
Bus
Santander (Estacion de Autobuses)
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
No tags
Bus
Santander (Estacion de Autobuses)
Madrid (South)
No tags
Bus
Santander (Estacion de Autobuses)
Avenida de América Metro
No tags
Next departures for Santander to Madrid on November 20
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Santander (Estacion de Autobuses)
Avenida de América Metro
Cheapest
Bus
Santander (Estacion de Autobuses)
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
Fastest
Bus
Santander (Estacion de Autobuses)
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
No tags
Bus
Santander (Estacion de Autobuses)
Madrid (South)
No tags
Bus
Santander (Estacion de Autobuses)
Avenida de América Metro
No tags
Next departures for Santander to Madrid on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Santander (Estacion de Autobuses)
Avenida de América Metro
Cheapest
Bus
Santander (Estacion de Autobuses)
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
Fastest
Bus
Santander (Estacion de Autobuses)
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
No tags
Bus
Santander (Estacion de Autobuses)
Madrid (South)
No tags
Bus
Santander (Estacion de Autobuses)
Avenida de América Metro
No tags
Next departures for Santander to Madrid on November 22
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Santander (Estacion de Autobuses)
Avenida de América Metro
Cheapest
Bus
Santander (Estacion de Autobuses)
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
Fastest
Bus
Santander (Estacion de Autobuses)
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
No tags
Bus
Santander (Estacion de Autobuses)
Madrid (South)
No tags
Bus
Santander (Estacion de Autobuses)
Avenida de América Metro
No tags
Next departures for Santander to Madrid on November 23
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Santander (Estacion de Autobuses)
Avenida de América Metro
Cheapest
Bus
Santander (Estacion de Autobuses)
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
Fastest
Bus
Santander (Estacion de Autobuses)
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
No tags
Bus
Santander (Estacion de Autobuses)
Madrid (South)
No tags
Bus
Santander (Estacion de Autobuses)
Avenida de América Metro
No tags
Next departures for Santander to Madrid on November 24
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Santander (Estacion de Autobuses)
Avenida de América Metro
Cheapest
Bus
Santander (Estacion de Autobuses)
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
Fastest
Bus
Santander (Estacion de Autobuses)
Aeropuerto Adolfo Suárez Madrid-Barajas, MAD T4
No tags
Bus
Santander (Estacion de Autobuses)
Madrid (South)
No tags
Bus
Santander (Estacion de Autobuses)
Avenida de América Metro
No tags
Last refresh of the prices: Today at 4:44 AM CET.
Compare 3 ways to go from Santander to Madrid
We recommend carpooling
Among the sustainable travel choices, the carpool stands out as the good way to reach Madrid. The journey takes about 4 hours 20 minutes and with fares starting at just $19, it presents an excellent value for a comfortable ride.
According to 41 reviews, ALSA received a 4.4-star rating for this journey. Travelers were especially satisfied with the staff and the timeliness, but some complained about the temperature. ALSA ticket prices on this trip start at $44
ALSA Santander Madrid recent customer reviews
To indicate in english that the bus is stopping in Burgos for a while would be great. The information was given only in spanish.
5 out of 5 stars
Anita K.
I did not have any contact with staff other than when the driver took my ticket so really I cannot really rate them, otherwise the trip was very smooth.
5 out of 5 stars
Terence P.
Free cold water was a bonus and much needed thankyou
Bus very clean and nice having movies
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Mendez Alvaro, 83, , Madrid, 28045, SpainEstación Sur
E - Madrid Interc. Plaza Castilla
Madrid Interc. Plaza Castilla, 28046 Madrid, Spain
F - Ronda de Valencia 6
Ronda de Valencia 6, 28012 Madrid, Spain
Frequently asked questions about traveling from Santander to Madrid by bus
What is the travel distance from Santander to Madrid?
About 211 miles (340 km) separate Santander and Madrid.
What are the departure and arrival stations when taking the bus from Santander to Madrid?
The majority of buses traveling from Santander to Madrid start their journey at Calle Navas de Tolosa, 2 and wind up at Madrid-Barajas Airport. These are the main departure and arrival locations on this route, but you could find others that could be a better fit for your travel plans.
What are the best sights and things to do in Madrid?
Once in Madrid, you can start exploring the city and discover its surroundings. The top sights and things to do are Thyssen-Bornemisza Museum, Palacio Real, Real Madrid at Santiago Bernabéu, Puerta del Sol and Plaza Mayor.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/16
$117
11/17
$87
Today
$38
11/19
$38
11/20
$38
11/21
$38
11/22
$38
11/23
$38
The cheapest trip from Santander to Madrid was searched and found on Nov 21, 2025 with a price of $38
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Santander to Madrid, as early as possible.
You can expect to pay from $38 to $123 for a bus ticket from Santander to Madrid based on the last 2 days. You can expect to find the cheapest price for the trip at $38 which is on 2025-11-21.
Usually FlixBus will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
The cheapest trip from Santander to Madrid was searched and found on Nov 21, 2025 with a price of $38
