Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | San Ysidro Bus terminal | City of Portland | CheapestFastest |
Last refresh of the prices: Last Sunday at 8:36 PM PST.
Get from San Ysidro to Portland
The journey takes about 3 days, 8 hours 25 minutes and with fares starting at just $232, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Ysidro and Portland?
Stops in Portland
- A
Greyhound Station Portland Maine
389 Congress St, Portland, ME 04102, USA
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from San Ysidro, CA to Portland, ME by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from San Ysidro to Portland?
The cheapest bus tickets from San Ysidro to Portland start from $232. The average price for this route is around $247. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Ysidro to Portland?
The average bus trip duration from San Ysidro to Portland is 3d 8h, covering a distance of 2612 miles (4213 km). The quickest bus can get you there in 3d 8h and is operated by Greyhound.
Which bus companies service the San Ysidro to Portland route?
Several major bus companies operate on this route with 1 buses available per day.
What is the earliest and latest departure time for the bus from San Ysidro to Portland?
The earliest bus departs from San Ysidro to Portland at 6:55am. And the latest bus departs at 7:00pm.
What are the CO₂ emissions for the bus trip from San Ysidro to Portland?
A bus trip from San Ysidro to Portland generates an estimated 105 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Ysidro, CA to Portland, ME was searched and found on Feb 5, 2026 with a price of $225To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Ysidro, CA to Portland, ME, as early as possible.
You can expect to pay from $225 to $225 for a bus ticket from San Ysidro, CA to Portland, ME based on the last 2 days. You can expect to find the cheapest price for the trip at $225 which is on 2026-02-05.
Top traveled bus routes
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Popular bus departures from San Ysidro
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