Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
FlixBus + Greyhound Lines, Inc. | San Luis Obispo | 537-517 W. Jackson Blvd | Cheapest | |||||
FlixBus + Greyhound Lines, Inc. | San Luis Obispo | Downtown Greyhound Station | Fastest | |||||
 | Cal Poly Vista Grande Dining Complex | Chicago (Union Station), IL | No tags | |||||
FlixBus + Greyhound Lines, Inc. | San Luis Obispo | Chicago 95Th & Dan Ryan | No tags | |||||
| Cal Poly Vista Grande Dining Complex | Chicago (Union Station), IL | No tags |
Last refresh of the prices: Last Friday at 3:40 PM PST.
Compare 2 ways to go from San Luis Obispo to Chicago
Among the sustainable travel choices, the Bus stands out as a good way to reach Chicago. The journey takes about 2 days, 4 hours 45 minutes and with fares starting at just $225, it presents an excellent value for a comfortable ride.
Where are the popular stops in San Luis Obispo and Chicago?
Stops in San Luis Obispo
- A1730 Santa Rosa St, San Luis Obispo, CA 93401, USA
- B
San Luis Obispo Bus Stop
1460 Calle Joaquin, San Luis Obispo, CA 93405, USA
Stops in Chicago
- A630 W Harrison St, Chicago, IL 60607, USA
- C
Polk St & Canal St
500-536 W Polk St, Chicago IL 60607, USA - D
Tornado Bus S Kedzie Ave
2807 S Kedzie Ave, Chicago, IL 60623, USA - E
Cumberland CTA
5800 N Cumberland Ave, Chicago, IL 60631, USA - F
Turimex California Ave
2139 S California Ave, Chicago, IL 60608, USA
Compare bus companies
Based on 5754 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $241
Frequently asked questions about traveling from San Luis Obispo to Chicago by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from San Luis Obispo to Chicago?
The cheapest bus tickets from San Luis Obispo to Chicago start from $225. The average price for this route is around $258. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Luis Obispo to Chicago?
The average bus trip duration from San Luis Obispo to Chicago is 2d 4h, covering a distance of 1825 miles (2944 km). The quickest bus can get you there in 2d 11h and is operated by Amtrak.
Which bus companies service the San Luis Obispo to Chicago route?
Several major bus companies operate on this route with 3 buses available per day.
What is the earliest and latest departure time for the bus from San Luis Obispo to Chicago?
The earliest bus departs from San Luis Obispo to Chicago at 12:55pm. And the latest bus departs at 4:30pm.
What are the CO₂ emissions for the bus trip from San Luis Obispo to Chicago?
A bus trip from San Luis Obispo to Chicago generates an estimated 74 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from San Luis Obispo to Chicago was searched and found on Feb 3, 2026 with a price of $231To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Luis Obispo to Chicago, as early as possible.
You can expect to pay from $231 to $933 for a bus ticket from San Luis Obispo to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $231 which is on 2026-02-03.
What's the cheapest way to go from San Luis Obispo to Chicago?
The Bus is the cheapest travel choice for this destination
