How much is the bus ticket from San Diego to Buffalo?

The cheapest bus tickets from San Diego to Buffalo start from $225. The average price for this route is around $275. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.

How long is the bus ride from San Diego to Buffalo?

The average bus trip duration from San Diego to Buffalo is 3d 7h, covering a distance of 2187 miles (3528 km). The quickest bus can get you there in 2d 17h and is operated by Greyhound .

Which bus companies service the San Diego to Buffalo route?

Several major bus companies operate on this route with 11 buses available per day, including services from Greyhound , FlixBus .

What is the earliest and latest departure time for the bus from San Diego to Buffalo?

The earliest bus departs from San Diego to Buffalo at 6:45am. And the latest bus departs at 7:35pm.

What are the CO₂ emissions for the bus trip from San Diego to Buffalo?

A bus trip from San Diego to Buffalo generates an estimated 88 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.

What is the best bus company from San Diego to Buffalo?

According to Busbud customers, the highest-rated bus company on this route is Greyhound , with an average rating of 3.5 out of 5 stars based on 87435 reviews.

Which bus company has the best Wi-Fi from San Diego to Buffalo?

Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.

Which bus company has the most timely service from San Diego to Buffalo?

According to Busbud traveller reviews, the most timely bus company on this route is FlixBus , with a punctuality rating of 3.9 out of 5 stars.

Which bus company has the cleanest buses from San Diego to Buffalo?

According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus , with a cleanliness rating of 4.1 out of 5 stars.

Bus San Diego to Buffalo from $200 | Refundable Tickets

Next bus departures

Next departures for San Diego to Buffalo on December 21
Operated by	Vehicle type	Departure time	Departure location	Trip duration	Arrival time	Arrival location	Recommended
Greyhound Lines, Inc. + FlixBus	Bus	7:35pm	Greyhound Bus Stop	3d 9h	7:55am	Buffalo (BUF) Airport	Cheapest
	Bus	7:35pm	Greyhound Bus Stop	2d 17h	4:15pm	Niagara Frontier Transportation Authority	Fastest
FlixBus + Greyhound Lines, Inc.	Bus	3:55pm	San Diego (Old Town-FlixBus)	2d 21h	4:15pm	Niagara Frontier Transportation Authority	No tags
FlixBus + Greyhound Lines, Inc.	Bus	7:35am	San Diego (Old Town-FlixBus)	3d 7h	6:30pm	Buffalo (BUF) Airport	No tags
FlixBus + Greyhound Lines, Inc.	Bus	12:15pm	San Diego (Old Town-FlixBus)	3d 13h	4:40am	Buffalo (BUF) Airport	No tags

Last refresh of the prices: Yesterday at 10:22 PM PST.

Compare 2 ways to go from San Diego to Buffalo

We recommend taking the train

Among the sustainable travel choices, the train stands out as the good way to reach Buffalo. The journey takes about 2 days, 15 hours 43 minutes and with fares starting at just $610, it presents an excellent value for a comfortable ride.

2train per day

2d 15hAverage Duration

2187 milesDistance

321kgCO₂ emissions

	Average Price	Average Duration	CO₂ emissions	Actions
Bus	Average Price$225 - $338	Average Duration3d 7h	CO₂ emissions 88kg CO₂e
Train	Average Price$610 - $610	Average Duration2d 15h	CO₂ emissions 321kg CO₂e

Where are the popular stops in San Diego and Buffalo?

Stops in San Diego

A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA
B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA
C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA
D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA
E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA
F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA

Stops in Buffalo

A
Buffalo Airport
Visit page
B
Transportation Center
185 Ellicott St, Buffalo, NY 14203, USA
Visit page
C
Exchange Street Station
75 Exchange St, Buffalo, NY 14203, USA
Visit page

Compare bus companies

Greyhound

3.5/587,442 reviews

Staff3.6

Timeliness2.9

Cleanliness3.3

Wifi2.4

Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.

FlixBus

3.5/511,671 reviews

Staff4.1

Timeliness3.9

Cleanliness4.1

Wifi2.7

Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.

US bus companies: FlixBus, BlaBlaCar Bus, Greyhound, ALSA, Intercape, Trenitalia, Big Sky

Frequently asked questions about traveling from San Diego, CA, US to Buffalo, NY by bus

Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.

How much is the bus ticket from San Diego to Buffalo?
The cheapest bus tickets from San Diego to Buffalo start from $225. The average price for this route is around $275. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from San Diego to Buffalo?
The average bus trip duration from San Diego to Buffalo is 3d 7h, covering a distance of 2187 miles (3528 km). The quickest bus can get you there in 2d 17h and is operated by Greyhound.
Which bus companies service the San Diego to Buffalo route?
Several major bus companies operate on this route with 11 buses available per day, including services from Greyhound, FlixBus.
What is the earliest and latest departure time for the bus from San Diego to Buffalo?
The earliest bus departs from San Diego to Buffalo at 6:45am. And the latest bus departs at 7:35pm.
What are the CO₂ emissions for the bus trip from San Diego to Buffalo?
A bus trip from San Diego to Buffalo generates an estimated 88 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
What is the best bus company from San Diego to Buffalo?
According to Busbud customers, the highest-rated bus company on this route is Greyhound, with an average rating of 3.5 out of 5 stars based on 87435 reviews.
Which bus company has the best Wi-Fi from San Diego to Buffalo?
Based on reviews on Busbud, the bus company FlixBus has the best Wi-Fi rating with a score of 2.7.
Which bus company has the most timely service from San Diego to Buffalo?
According to Busbud traveller reviews, the most timely bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from San Diego to Buffalo?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is FlixBus, with a cleanliness rating of 4.1 out of 5 stars.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found

12/18

No data

12/19

$272

Today

$200

12/21

$395

12/22

No data

12/23

$254

12/24

No data

12/25

No data

The cheapest trip from San Diego, CA, US to Buffalo, NY was searched and found on Dec 20, 2025 with a price of $200

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Buffalo, NY, as early as possible.

You can expect to pay from $200 to $395 for a bus ticket from San Diego, CA, US to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at $254 which is on 2025-12-23.