Bus Tickets from San Diego, CA, US to Buffalo, NY

Previously seen trips

Next departures for San Diego to Buffalo on October 22
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound
San Diego (Old Town-FlixBus)
Buffalo (BUF) AirportNo tags
FlixBus + Greyhound
UCSD Health La Jolla Station
Buffalo (BUF) AirportNo tags
Greyhound + FlixBus
UCSD Health La Jolla Station
Buffalo (BUF) AirportNo tags
Greyhound + FlixBus
Greyhound Bus Stop
Buffalo (BUF) AirportNo tags
Greyhound
Greyhound Bus Stop
Niagara Frontier Transportation AuthorityNo tags

Accepted payments

  • Visa
  • MasterCard
  • American Express
  • China Union Pay
  • Diners Club Canada
  • Discover Click to Pay
  • JCB payment
  • Klarna (Pay over time)
  • Google Pay

Compare 2 ways to go from San Diego to Buffalo

Bus
Average Price$231 - $400Average Duration3d 7h
88kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average Price$458 - $497Average Duration2d 15h
321kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the bus from San Diego to Buffalo

Among the sustainable travel choices, the bus stands out as the good way to reach Buffalo. The journey takes about 3 days, 7 hours 55 minutes and with fares starting at just $231, it presents an excellent value for a comfortable ride.

16bus per day
3d 7hAverage Duration
$231Cheapest ticket
88kgCO₂ emissions

Bus San Diego, CA, US to Buffalo, NY: Trip Overview

Average ticket price$249
Average bus trip duration3d 7h
Number of daily buses16
Earliest bus departure6:45am
Distance2180 miles (3515 km)
Latest bus departure7:35pm

San Diego to Buffalo Bus

Busbud helps you find a bus from San Diego to Buffalo. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

Bus service from San Diego to Buffalo will be provided by the most trusted bus companies.

Discover how much the bus trip from San Diego to Buffalo will cost you. Use our filters and sorting features to find the cheapest bus tickets or luxury buses.

Frequently asked questions for your trip San Diego, CA, US - Buffalo, NY

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
10/20
No data
10/21
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Today
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10/23
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10/24
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10/25
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10/26
$234
10/27
No data
busbud logoThe cheapest trip from San Diego, CA, US to Buffalo, NY was searched and found on Oct 26, 2025 with a price of $234

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Buffalo, NY, as early as possible.

You can expect to pay from $234 to $234 for a bus ticket from San Diego, CA, US to Buffalo, NY based on the last 2 days. You can expect to find the cheapest price for the trip at $234 which is on 2025-10-26.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between San Diego and Buffalo!

Much more than a mere vehicle taking you from San Diego to Buffalo, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.

Buses have one of the smallest carbon footprints of motorized transport modes. A bus going from San Diego to Buffalo will emit less CO2 than a car or an airplane.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Diego to Buffalo.

Did you know?

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

9.2% of ground transportation in Europe is done by bus versus 7.4% by train.

The bus driver with the longest career in the world drove more than 2,000,000 miles and is a happy World Record holder.

What's the cheapest way to go from San Diego, CA, US to Buffalo, NY?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to San Diego, CA, US by bus?

Bus from Buffalo, NY to San Diego, CA, US

You can also go to Buffalo, NY by train

Train from San Diego, CA, US to Buffalo, NY

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travelers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud partners with safe and reliable bus companies throughout the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others so you can buy tickets without a worry.

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