Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Roanoke Bus Stop | Harrisburg Bus Station | CheapestFastest |
Last refresh of the prices: Today at 3:39 AM EST.
Compare 2 ways to go from Roanoke to Harrisburg
Among the sustainable travel choices, the bus stands out as the good way to reach Harrisburg. The journey takes about 9 hours 20 minutes and with fares starting at just $92, it presents an excellent value for a comfortable ride.
Where are the popular stops in Roanoke and Harrisburg?
Stops in Roanoke
- AExit 140 (Park and Ride), Virginia 24153, USA
Stops in Harrisburg
- A
Harrisburg Bieber Greyhound Station
411 Market St, Harrisburg, PA 17101
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Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Roanoke to Harrisburg by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from Roanoke to Harrisburg?
The cheapest bus tickets from Roanoke to Harrisburg start from $92. The average price for this route is around $136. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from Roanoke to Harrisburg?
The average bus trip duration from Roanoke to Harrisburg is 9h 20m, covering a distance of 264 miles (426 km). The quickest bus can get you there in 9h 20m and is operated by Greyhound.
Which bus companies service the Roanoke to Harrisburg route?
Several major train operators operate on this route with 1 trains available per day.
What is the earliest and latest departure time for the bus from Roanoke to Harrisburg?
The earliest bus departs from Roanoke to Harrisburg at 4:35am. And the latest bus departs at 4:35am.
What are the CO₂ emissions for the bus trip from Roanoke to Harrisburg?
A bus trip from Roanoke to Harrisburg generates an estimated 11 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Roanoke to Harrisburg was searched and found on Dec 25, 2025 with a price of $102To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Roanoke to Harrisburg, as early as possible.
You can expect to pay from $102 to $156 for a bus ticket from Roanoke to Harrisburg based on the last 2 days. You can expect to find the cheapest price for the trip at $102 which is on 2025-12-25.
What's the cheapest way to go from Roanoke to Harrisburg?
The bus is the cheapest travel choice for this destination
