Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
Greyhound Lines, Inc. + FlixBus | Bus | Mesa Bus Stop | San Diego (Old Town-FlixBus) | Cheapest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Mesa Bus Stop | UCSD Health La Jolla Station | Fastest | ||||
 | Bus | Mesa Bus Stop | Greyhound Bus Stop | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Mesa Bus Stop | Downtown SD (Seaport) | No tags |
Last refresh of the prices: Yesterday at 12:13 PM MST.
Get from Mesa to San Diego
The journey takes about 15 hours 35 minutes and with fares starting at just $77, it presents an excellent value for a comfortable ride.
Where are the popular stops in Mesa and San Diego?
Stops in Mesa
- A
Mesa Bus Station
1423 S Country Club , Mesa, AZ 85210, USA
Stops in San Diego
- A
Mission Valley Sheraton
1433 Camino del Rio S, San Diego, CA 92108, USA - B
Old Town Courtyard Marriot
2435 Jefferson St, San Diego, CA 92110, USA - C
Downtown Holiday Inn
1617 1st Ave, San Diego, CA 92101, USA - D
Greyhound Station
1313 National Ave, San Diego, CA 92101, USA - E
Market St. & Park Blvd
601 Park Boulevard, San Diego, CA 92101, USA - F
San Ysidro McDonald's
727 E San Ysidro Blvd, San Diego, CA 92173, USA
Compare bus companies
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Mesa to San Diego, CA, US by bus
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Mesa to San Diego, CA, US was searched and found on Nov 26, 2025 with a price of $84To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Mesa to San Diego, CA, US, as early as possible.
You can expect to pay from $84 to $119 for a bus ticket from Mesa to San Diego, CA, US based on the last 2 days. You can expect to find the cheapest price for the trip at $84 which is on 2025-11-26.
