Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | La Serena (Bus terminal La Serena) | Talca (Cruce Varoli) | CheapestFastest | ||||
Andimar + Flixbus Chile | Bus | La Serena (Bus terminal La Serena) | Talca (Cruce Varoli) | No tags | ||||
| Bus | La Serena (Bus terminal La Serena) | Talca (Cruce Varoli) | No tags | ||||
Andimar + Flixbus Chile | Bus | La Serena (Bus terminal La Serena) | Talca (Cruce Varoli) | No tags | ||||
| Bus | La Serena (Bus terminal La Serena) | Talca (Cruce Varoli) | No tags |
Last refresh of the prices: Yesterday at 10:29 AM -03.
Get from La Serena to Talca
The journey takes about 10 hours 50 minutes and with fares starting at just $20, it presents an excellent value for a comfortable ride.
Where are the popular stops in La Serena and Talca?
Stops in La Serena
- AAmunátegui 107, La Serena, Región de Coquimbo, Chile
- B
Rotonda La Serena
Panamericana Norte 208, La Serena, Región de Coquimbo, Chile
Stops in Talca
- ADos Sur / Doce y Trece Oriente, Talca, VII Región, Chile
- B
Parada de Autobus Talca Varoli
Rho 1131, Talca, VII Región, Chile - C
Parada de Autobus Talca Cruce Varoli
Veintiuno Ote 253, Talca, VII Región, Chile - D
Estación de Ferrocarriles de Talca
Once Ote 900-1002, Talca, VII Región, Chile - E
Terminal Tur Bus de Talca
Trece Ote 851-889, Talca, VII Región, Chile - F
Cruce Sur San Javier
Sgto Aldea 2456, San Javier, VII Región, Chile
Compare bus companies
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from La Serena, CL to Talca by bus
Please note that schedules, routes, or operator details shown here may be updated or vary at the time of your trip.
How much is the bus ticket from La Serena to Talca?
The cheapest bus tickets from La Serena to Talca start from $20. The average price for this route is around $28. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus ride from La Serena to Talca?
The average bus trip duration from La Serena to Talca is 10h 50m, covering a distance of 382 miles (617 km). The quickest bus can get you there in 10h 10m and is operated by FlixBus.
Which bus companies service the La Serena to Talca route?
Several major train operators operate on this route with 4 trains available per day.
What is the earliest and latest departure time for the bus from La Serena to Talca?
The earliest bus departs from La Serena to Talca at 3:20am. And the latest bus departs at 11:59pm.
What are the CO₂ emissions for the bus trip from La Serena to Talca?
A bus trip from La Serena to Talca generates an estimated 15 kg of CO₂, making it a highly eco-friendly travel option and recommended mode of travel by Busbud.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from La Serena, CL to Talca was searched and found on Nov 29, 2025 with a price of $21To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from La Serena, CL to Talca, as early as possible.
You can expect to pay from $21 to $31 for a bus ticket from La Serena, CL to Talca based on the last 2 days. You can expect to find the cheapest price for the trip at $21 which is on 2025-11-29.
