Next departures for Frankfurt am Main to Lyon on November 19
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Frankfurt Hbf
Perrache
CheapestFastest
Bus
FRA Frankfurt airport
Aéroport LYS
No tags
Bus
FRA Frankfurt airport
Perrache
No tags
Bus
FRA Frankfurt airport
Perrache
No tags
Bus
Frankfurt Hbf
Aéroport LYS
No tags
Next departures for Frankfurt am Main to Lyon on November 20
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Frankfurt - Main bus station
Lyon - Perrache Bus Station
Cheapest
Bus
Frankfurt Main Airport P36
Lyon - Perrache Bus Station
Fastest
Bus
Hbf
de Perrache - Galerie A
No tags
Bus
Hbf
Perrache
No tags
Next departures for Frankfurt am Main to Lyon on November 21
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Frankfurt - Main bus station
Lyon - Perrache Bus Station
Cheapest
Bus
Frankfurt Main Airport P36
Lyon - Perrache Bus Station
Fastest
Bus
Frankfurt - Main bus station
Lyon - Perrache Bus Station
No tags
Bus
Frankfurt Main Airport P36
Lyon - Perrache Bus Station
No tags
Next departures for Frankfurt am Main to Lyon on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Frankfurt - Main bus station
Lyon - Perrache Bus Station
Cheapest
Bus
Frankfurt Main Airport P36
Lyon - Perrache Bus Station
Fastest
Last refresh of the prices: Yesterday at 3:07 PM CET.
Compare 3 ways to go from Frankfurt am Main to Lyon
We recommend carpooling
Among the sustainable travel choices, the carpool stands out as the good way to reach Lyon. The journey takes about 7 hours 10 minutes and with fares starting at just $46, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Based on 11138 reviews, the company was rated 3.7 stars on Busbud. Travelers were especially satisfied with the ticket access and the staff but often complained with the wifi. BlaBlaCar Bus ticket prices on this trip start at $39
Based on 1206 reviews, the company was rated 3.6 stars on Busbud. Travelers were especially satisfied with the ticket access and the cleanliness but often complained with the wifi. Sindbad ticket prices on this trip start at $71
Frequently asked questions about traveling from Frankfurt am Main to Lyon by bus
What is the distance between Frankfurt am Main and Lyon?
Frankfurt am Main and Lyon are 350 miles (564 km) apart.
What are the departure and arrival stations when taking the bus from Frankfurt am Main to Lyon?
If you're headed to Lyon from Frankfurt am Main, chances are that your bus will depart from Frankfurt Airport and arrive at Lyon Airport. These are the main pick-up and drop-off locations on this route, but you can also find other options that could better fit your plans.
What are the best sights and things to do in Lyon?
Once in Lyon, you can start exploring the city and discover its surroundings. The top sights and things to do are Boat Trips, La Place des Terreaux/Bartholdi Fountain, Musée des Beaux Arts, Basilique Notre Dame de Fourviere and Le Centre d’Histoire de la Résistance et de la Déportation.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/17
$53
11/18
$48
Today
$41
11/20
$36
11/21
$36
11/22
$38
11/23
$36
11/24
$37
The cheapest trip from Frankfurt am Main to Lyon was searched and found on Nov 21, 2025 with a price of $36
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Frankfurt am Main to Lyon, as early as possible.
You can expect to pay from $36 to $74 for a bus ticket from Frankfurt am Main to Lyon based on the last 2 days. You can expect to find the cheapest price for the trip at $36 which is on 2025-11-21.
Usually Sindbad will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Frankfurt am Main to Lyon?
The bus is the cheapest travel choice for this destination
The cheapest trip from Frankfurt am Main to Lyon was searched and found on Nov 21, 2025 with a price of $36
The bus is the cheapest travel choice for this destination
