Next departures for Detroit to Syracuse on November 24
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Amtrak Station
Amtrak Station
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Amtrak Station
SYR Airport
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Amtrak Station
SYR Airport
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Amtrak Station
Amtrak Station
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Last refresh of the prices: Yesterday at 3:38 PM EST.
Compare 2 ways to go from Detroit to Syracuse
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach Syracuse. The journey takes about 13 hours 20 minutes and with fares starting at just $77, it presents an excellent value for a comfortable ride.
Based on 5597 reviews, the company was rated 4.1 stars on Busbud. Travelers were especially satisfied with the seats and the ticket access but often complained with the wifi. Amtrak ticket prices on this trip start at $116
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Detroit Syracuse recent customer reviews
One of my busses was canceled and still never refunded
Frequently asked questions about traveling from Detroit, MI to Syracuse, US by bus
What is the travel distance from Detroit to Syracuse?
The distance separating Detroit and Syracuse is 354 miles (570 km).
What are the departure and arrival stations when taking the bus from Detroit to Syracuse?
The majority of buses traveling from Detroit to Syracuse start their journey at Detroit Bus Station and wind up at Regional Transportation Center. These are the most popular departure and arrival locations on this route, but you can also find other options that could better fit your plans.
What are the best sights and things to do in Syracuse?
Once in Syracuse, you can start exploring the city and discover its surroundings. The top sights and things to do are MOST, NBT Bank Stadium, Erie Canal Museum, Webster Pond and Onondaga Lake Park.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/19
No data
11/20
$73
Today
No data
11/22
No data
11/23
No data
11/24
$220
11/25
No data
11/26
No data
The cheapest trip from Detroit, MI to Syracuse, US was searched and found on Nov 20, 2025 with a price of $73
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Detroit, MI to Syracuse, US, as early as possible.
You can expect to pay from $73 to $1,205 for a bus ticket from Detroit, MI to Syracuse, US based on the last 2 days. You can expect to find the cheapest price for the trip at $220 which is on 2025-11-24.
What's the cheapest way to go from Detroit, MI to Syracuse, US?
The bus is the cheapest travel choice for this destination
The cheapest trip from Detroit, MI to Syracuse, US was searched and found on Nov 20, 2025 with a price of $73
The bus is the cheapest travel choice for this destination
