Next departures for Chicago to Syracuse on November 25
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Syracuse (Regional Transportation Center)
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Syracuse (Regional Transportation Center)
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
537-517 W. Jackson Blvd
Syracuse (Regional Transportation Center)
No tags
Next departures for Chicago to Syracuse on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Syracuse (Regional Transportation Center)
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Syracuse (Regional Transportation Center)
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
537-517 W. Jackson Blvd
Syracuse (Regional Transportation Center)
No tags
Next departures for Chicago to Syracuse on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Syracuse (Regional Transportation Center)
CheapestFastest
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Syracuse (Regional Transportation Center)
No tags
Greyhound Lines, Inc. + FlixBus
Bus
537-517 W. Jackson Blvd
Syracuse (Regional Transportation Center)
No tags
Next departures for Chicago to Syracuse on November 28
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Chicago 95Th & Dan Ryan
Syracuse (Regional Transportation Center)
CheapestFastest
Bus
Downtown Greyhound Station
Syracuse (Regional Transportation Center)
No tags
Greyhound Lines, Inc. + FlixBus
Bus
537-517 W. Jackson Blvd
Syracuse (Regional Transportation Center)
No tags
Next departures for Chicago to Syracuse on November 29
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Syracuse (Regional Transportation Center)
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Syracuse (Regional Transportation Center)
Fastest
Next departures for Chicago to Syracuse on November 30
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Syracuse (Regional Transportation Center)
CheapestFastest
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Syracuse (Regional Transportation Center)
No tags
Greyhound Lines, Inc. + FlixBus
Bus
537-517 W. Jackson Blvd
Syracuse (Regional Transportation Center)
No tags
Next departures for Chicago to Syracuse on December 1
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Syracuse (Regional Transportation Center)
CheapestFastest
FlixBus + Greyhound Lines, Inc.
Bus
Downtown Greyhound Station
Syracuse (Regional Transportation Center)
No tags
Next departures for Chicago to Syracuse on December 2
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
Bus
Downtown Greyhound Station
Syracuse (Regional Transportation Center)
Cheapest
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Syracuse (Regional Transportation Center)
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
537-517 W. Jackson Blvd
Syracuse (Regional Transportation Center)
No tags
Last refresh of the prices: Yesterday at 9:47 PM CST.
Compare 2 ways to go from Chicago to Syracuse
We recommend taking the train
Among the sustainable travel choices, the train stands out as the good way to reach Syracuse. The journey takes about 12 hours 58 minutes and with fares starting at just $60, it presents an excellent value for a comfortable ride.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Frequently asked questions about traveling from Chicago to Syracuse, US by bus
How far is Chicago from Syracuse?
Chicago and Syracuse are 592 miles (954 km) apart.
What are the departure and arrival stations when taking the bus from Chicago to Syracuse?
Most of the buses traveling from Chicago to Syracuse leave from Downtown Greyhound Station and arrive at Regional Transportation Center. These are the primary departure and arrival locations on this route, but you could find others that could be a better fit for your travel plans.
What are the best sights and things to do in Syracuse?
Once in Syracuse, you can start exploring the city and discover its surroundings. The top sights and things to do are Webster Pond, NBT Bank Stadium, WonderWorks, Oncenter War Memorial Arena and Onondaga Lake Park.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/22
No data
11/23
$96
Today
$98
11/25
$98
11/26
$103
11/27
No data
11/28
$199
11/29
$134
The cheapest trip from Chicago to Syracuse, US was searched and found on Nov 23, 2025 with a price of $96
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Syracuse, US, as early as possible.
You can expect to pay from $96 to $227 for a bus ticket from Chicago to Syracuse, US based on the last 2 days. You can expect to find the cheapest price for the trip at $98 which is on 2025-11-25.