Next departures for Chicago to Spartanburg on November 26
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Spartanburg
CheapestFastest
Bus
Downtown Greyhound Station
Spartanburg
No tags
Bus
537-517 W. Jackson Blvd
Spartanburg
No tags
Next departures for Chicago to Spartanburg on November 27
Operated by
Vehicle type
Departure time
Departure location
Trip duration
Arrival time
Arrival location
Recommended
Price and booking link
FlixBus + Greyhound Lines, Inc.
Bus
Chicago 95Th & Dan Ryan
Spartanburg
Cheapest
Bus
Downtown Greyhound Station
Spartanburg
Fastest
Greyhound Lines, Inc. + FlixBus
Bus
Downtown Greyhound Station
Spartanburg
No tags
Bus
Downtown Greyhound Station
Spartanburg
No tags
Greyhound Lines, Inc. + FlixBus
Bus
Downtown Greyhound Station
Spartanburg
No tags
Last refresh of the prices: Yesterday at 12:27 PM CST.
Compare 2 ways to go from Chicago to Spartanburg
We recommend taking the bus
Among the sustainable travel choices, the bus stands out as the good way to reach Spartanburg. The journey takes about 1 day, 2 hours 45 minutes and with fares starting at just $110, it presents an excellent value for a comfortable ride.
Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Greyhound Chicago Spartanburg recent customer reviews
Buses were over loaded to say we are in the middle of a pandemic.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Chicago to Spartanburg by bus
What is the travel distance from Chicago to Spartanburg?
The distance between the two cities is 568 miles (916 km).
What are the departure and arrival stations when taking the bus from Chicago to Spartanburg?
The majority of buses traveling from Chicago to Spartanburg start their journey at Downtown Greyhound Station and wind up at Super Acapulco. These are the primary departure and arrival locations on this route, but you can also find other options that could better fit your plans.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/24
$263
11/25
No data
Today
$268
11/27
$155
11/28
No data
11/29
No data
11/30
No data
12/01
No data
The cheapest trip from Chicago to Spartanburg was searched and found on Nov 27, 2025 with a price of $155
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Chicago to Spartanburg, as early as possible.
You can expect to pay from $155 to $309 for a bus ticket from Chicago to Spartanburg based on the last 2 days. You can expect to find the cheapest price for the trip at $155 which is on 2025-11-27.
What's the cheapest way to go from Chicago to Spartanburg?
The bus is the cheapest travel choice for this destination