Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Flixbus is a European bus operator that offers intercity and bus travel in over 38 countries. Known for their easy-to-spot lime green buses and for offering affordable transportation between cities in Europe and the Americas, Flixbus is a good option for those looking for an affordable, reliable bus company. In their buses, you'll find free WiFi, bathrooms, and power outlets. You can also pay extra to choose your seat and get extra legroom, or even buy a snack or drink onboard directly from the driver. You can reschedule your ticket for a small fee, which varies from $1 to $5, depending on how close you are to the departure date.
Frequently asked questions about traveling from Buffalo, NY to Portland, ME by bus
What is the travel distance from Buffalo to Portland?
About 437 miles (704 km) separate Buffalo and Portland.
What are the departure and arrival stations when taking the bus from Buffalo to Portland?
The majority of buses traveling from Buffalo to Portland start their journey at Buffalo Airport and wind up at Greyhound Station Portland Maine. These are the main pick-up and drop-off locations on this route, but you can also find other options that could better fit your plans.
What are the best sights and things to do in Portland?
Once in Portland, you can start exploring the city and discover its surroundings. The top sights and things to do are Oregon Museum of Science and Industry, Food Cart Pods, Portland Art Museum, Lan Su Chinese Garden and Coffee Culture.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/24
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11/25
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Today
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11/27
$151
11/28
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11/29
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11/30
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12/01
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The cheapest trip from Buffalo, NY to Portland, ME was searched and found on Nov 27, 2025 with a price of $151
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Buffalo, NY to Portland, ME, as early as possible.
You can expect to pay from $151 to $151 for a bus ticket from Buffalo, NY to Portland, ME based on the last 2 days. You can expect to find the cheapest price for the trip at $151 which is on 2025-11-27.