Greyhound Lines offers the most comprehensive intercity bus services in the United States. They operate a modern, environmentally friendly fleet that serves more than 2400 destinations and carries nearly 16 million passengers annually. When traveling with them, you can expect free WiFi, onboard entertainment, bathrooms, power outlets and decent legroom. One of the great perks of Greyhound is that they connect big cities and smaller towns in the US, where you usually can't get to by train or plane. If you're looking for safe and affordable transportation, Greyhound is a great choice.
Founded in 1919, Jefferson Lines provides bus services across the Midwest in the US. Their buses have WiFi, USB plugs, bathrooms, reclining seats, reading lights and GPS tracking. Tickets are non-refundable, but you can change the date by paying a fee. Known for their affordable prices and convenient schedules, if you're looking to travel in the Midwest, Jefferson Lines is the way to go.
Frequently asked questions about traveling from Ames, IA, US to Chicago by bus
What is the travel distance from Ames to Chicago?
The distance between the two cities is 308 miles (496 km).
What are the departure and arrival stations when taking the bus from Ames to Chicago?
The majority of buses traveling from Ames to Chicago start their journey at Intermodal Facility and wind up at Downtown Greyhound Station. These are the primary departure and arrival locations on this route, but you can find others that could fit better into your travel plans.
What are the best sights and things to do in Chicago?
Once in Chicago, you can start exploring the city and discover its surroundings. The top sights and things to do are Architectural River Cruise, Lincoln Park Zoo, Cloud Gate, The Field Museum and Lake Michigan.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
Best price found
11/22
$69
11/23
$78
Today
$80
11/25
$141
11/26
$141
11/27
$61
11/28
$59
11/29
$61
The cheapest trip from Ames, IA, US to Chicago was searched and found on Nov 28, 2025 with a price of $59
To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Ames, IA, US to Chicago, as early as possible.
You can expect to pay from $59 to $141 for a bus ticket from Ames, IA, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at $59 which is on 2025-11-28.
The cheapest trip from Ames, IA, US to Chicago was searched and found on Nov 28, 2025 with a price of $59
