Find coaches from San Diego, CA, US to Chicago

Next departures

Next departures from San Diego to Chicago on 4 November
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus + Greyhound Lines, Inc.
    		UCSD Health La Jolla Station
    		Chicago 95Th & Dan RyanCheapest
    FlixBus + Greyhound Lines, Inc.
      		UCSD Health La Jolla Station
      		Downtown Greyhound StationFastest
      FlixBus + Greyhound Lines, Inc.
        		San Diego (Old Town-FlixBus)
        		Downtown Greyhound StationNo tags
        Greyhound Lines, Inc.
          		Greyhound Bus Stop
          		Downtown Greyhound StationNo tags
          FlixBus + Greyhound Lines, Inc.
            		San Diego (Old Town-FlixBus)
            		Downtown Greyhound StationNo tags

            Last refresh of the prices: Last Saturday at 11:16 PM PDT.

            Accepted payments

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            Compare 2 ways to travel from San Diego to Chicago

            We recommend taking the bus

            Among the sustainable travel choices, the bus stands out as a good way to reach Chicago. The journey takes about 2 days, 6 hours 35 minutes and with fares starting at just US$120, it presents an excellent value for a comfortable ride.

            33bus per day
            2d 6hAverage duration
            2787 kmDistance
            70kgCO₂ emissions
            Bus
            		Average priceUS$120 - US$772Average duration2d 6h
            70kg CO₂e
            Train
            		Average priceUS$186 - US$347Average duration1d 22h
            254kg CO₂e

            Bus San Diego, CA, US to Chicago: Trip Overview

            Average ticket priceUS$185
            Average bus trip duration2d 6h
            Number of daily buses33
            Earliest bus departure06:45
            Distance2786 km
            Latest bus departure19:35

            San Diego to Chicago Bus

            With Busbud, comparing and booking tickets for a bus from San Diego to Chicago is a breeze. Browse through an extensive selection of bus fares and bus schedules to find the best deals.

            We make it our job to connect you with the most dependable bus companies that cover bus service from San Diego to Chicago.

            From cheap bus tickets to more luxurious buses travelling from San Diego to Chicago, we offer a wide range of bus services to best suit your needs depending on how much your budget is.

            Frequently asked questions on the trip San Diego, CA, US - Chicago

            1. How much does a bus ticket from San Diego to Chicago cost?

              The bus ticket price from San Diego to Chicago starts at US$120. The best way to find cheap bus tickets from San Diego to Chicago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!

            2. How long is the bus ride from San Diego to Chicago?

              The average travel time between San Diego and Chicago is around 2d 6h, although the fastest bus will take about 2d 1h. This is the time it takes to travel the 2788 km that separates the two cities.

            3. How many daily bus connections are there between San Diego and Chicago?

              The number of buses from San Diego to Chicago can differ depending on the day of the week. On average, there are 33 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from San Diego to Chicago by comparing and selecting the bus that fits your travel style and budget on Busbud.

            4. Which bus companies travel from San Diego to Chicago?

              When taking the bus from San Diego to Chicago, you can travel comfortably and safely with Greyhound, Amtrak, FlixBus.

            5. What are the departure and arrival stations when taking the bus from San Diego to Chicago?

              Buses travelling between San Diego and Chicago leave from Mission Valley Sheraton or Old Town Courtyard Marriot and arrive at Downtown Greyhound Station, Chicago O'Hare International Airport, Polk St & Canal St.

            Find cheapest prices for buses

            Price is for a one-way ticket for one passenger and based on past searches.

            Best price found
            01/11
            US$381
            02/11
            US$342
            Today
            US$430
            04/11
            US$256
            05/11
            US$300
            06/11
            US$264
            07/11
            US$264
            08/11
            US$181
            busbud logoThe cheapest trip from San Diego, CA, US to Chicago was searched and found on 08 Nov 2025 with a price of US$181

            To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from San Diego, CA, US to Chicago as early as possible.

            You can expect to pay from US$181 to US$2 279 for a bus ticket from San Diego, CA, US to Chicago based on the last 2 days. You can expect to find the cheapest price for the trip at US$181, which is on 2025-11-08.

            About Bus Travel

            Bus Travel Tips

            Meet and talk to locals at the bus stations while travelling from San Diego to Chicago.There is no better way to get inside travel information while exploring a new city than to go straight to its people.

            From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from San Diego to Chicago.

            Taking the bus creates the smallest carbon footprint compared to other modes of transport. Not to mention that buses will allow you to discover scenic gems from San Diego to Chicago that are otherwise impossible to come by with a plane.

            Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from San Diego to Chicago.

            Did you know?

            Did you know some bus companies in Germany offer to their passenger low-costs snacks and regional beer based on their destination? Prosit!

            One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

            The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

            What's the cheapest way to go from San Diego, CA, US to Chicago?

            busbud logoThe bus is the cheapest travel choice for this destination

            Will you be returning to San Diego, CA, US by bus?

            Bus from Chicago to San Diego, CA, US

            You can also go to Chicago by train

            Train from San Diego, CA, US to Chicago

            Why choose Busbud?

            The Best Way To Book Bus and Train Tickets

            Busbud.com makes it easy for you to find, compare and book city-to-city bus tickets, all over the world. We save you the extra trip to the bus station. With Busbud, wherever you go, you have a worldwide bus station within reach and available in your own language and currency. With Busbud, you can buy tickets with confidence. We ensure that you make the most out of your bus trip by partnering up with reliable bus companies from all around the world such as Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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