Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | City of Portland | Gateway Station | CheapestFastest | |||||
 | Portland Transportation Center | Gateway Station | No tags | |||||
| Portland Transportation Center | Gateway Station | No tags |
Last refresh of the prices: Last Tuesday at 6:34 PM EST.
Compare 2 ways to travel from Portland to St. Louis
Among the sustainable travel choices, the bus stands out as a good way to reach St. Louis. The journey takes about 1 day, 10 hours 40 minutes and with fares starting at just R 2 875, it presents an excellent value for a comfortable ride.
Where are the popular stops in Portland and St. Louis?
Stops in Portland
- A
Greyhound Station Portland Maine
389 Congress St, Portland, ME 04102, USA
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Frequently asked questions about travelling from Portland, ME to St. Louis by bus
Please note that timetables, routes, or operator details shown here may be updated or differ at the time of your trip.
How much is the bus ticket from Portland to St. Louis?
The cheapest bus tickets from Portland to St. Louis start at R 2 875. The average price for this route is around R 4 007. Busbud recommends booking your tickets in advance for the best chance of getting the lowest possible price.
How long is the bus journey from Portland to St. Louis?
The average bus journey time from Portland to St. Louis is 1d 10h, covering a distance of 1755 km. The fastest bus gets you there in 1d 10h and is operated by Amtrak.
Which bus companies service the Portland to St. Louis route?
What is the earliest and latest departure time for the bus from Portland to St. Louis?
The earliest bus departs from Portland to St. Louis at 13:45. And the latest bus departs at 13:45.
What are the CO₂ emissions for the bus trip from Portland to St. Louis?
A bus trip from Portland to St. Louis produces an estimated 44 kg of CO₂, making it a highly eco-friendly travel option and Busbud’s recommended way to travel.
What is the best bus company from Portland to St. Louis?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5696 reviews.
Which bus company has the best Wi-Fi from Portland to St. Louis?
Based on reviews on Busbud, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company offers the most punctual service from Portland to St. Louis?
According to Busbud traveller reviews, the most punctual bus company on this route is Amtrak, with a punctuality rating of 3.8 out of 5 stars.
Which bus company has the cleanest buses from Portland to St. Louis?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Portland, ME to St. Louis was searched and found on 12 Jan 2026 with a price of R 2 196To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Portland, ME to St. Louis as early as possible.
You can expect to pay from R 2 196 to R 37 626 for a bus ticket from Portland, ME to St. Louis based on the last 2 days. You can expect to find the cheapest price for the trip at R 2 196, which is on 2026-01-12.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Portland, ME to St. Louis?
The Bus is the cheapest travel choice for this destination
