Next departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Calama (Terminale de buses Granaderos) | Terminal San Borja | Cheapest | |||||
 | Terminal de buses Calama | Terminal de Buses San Borja - San Francisco de Borja | Fastest | |||||
| Calama | Terminal de Buses San Borja - San Francisco de Borja | No tags | |||||
 | Av. Balmaceda | San Borja | No tags | |||||
Andimar + Flixbus Chile | Calama (Terminale de buses Granaderos) | Santiago (Los Libertadores) | No tags |
Last refresh of the prices: Today at 1:17 AM -04.
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Get from Calama to Santiago
The journey takes about 21 hours, and with fares starting at just US$36, it presents an excellent value for a comfortable ride.
Bus Calama to Santiago, CL: Trip Overview
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Calama to Santiago Bus
Busbud helps you find a bus from Calama to Santiago. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.
Bus service from Calama to Santiago will be provided by the most trusted bus companies.
Whether it is cheap bus tickets or more luxurious buses going to Santiago from Calama, we help you find what you're looking for based on how much of a budget you have.
Where are the popular stops in Calama and Santiago?
Frequently asked questions on the trip Calama - Santiago, CL
How much does a bus ticket from Calama to Santiago cost?
The bus ticket price from Calama to Santiago starts at US$36. The best way to find cheap bus tickets from Calama to Santiago is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the bus ride from Calama to Santiago?
The average travel time between Calama and Santiago is around 21h, although the fastest bus will take about 18h 20m. This is the time it takes to travel the 1232 km that separates the two cities.
How many daily bus connections are there between Calama and Santiago?
The number of buses from Calama to Santiago can differ depending on the day of the week. On average, there are 20 on this route. Some buses run direct routes, while others have layovers. Simplify your bus trip from Calama to Santiago by comparing and selecting the bus that fits your travel style and budget on Busbud.
Which bus companies travel from Calama to Santiago?
When taking the bus from Calama to Santiago, you can travel comfortably and safely with Pluss Chile, Cikbus Elité, Buses Andimar.
What are the departure and arrival stations when taking the bus from Calama to Santiago?
Buses travelling between Calama and Santiago leave from Av. Balmaceda or Calama and arrive at San Borja, Terminal Sur, Terminal Los Héroes.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Calama to Santiago, CL was searched and found on 07 Nov 2025 with a price of US$36To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Calama to Santiago, CL as early as possible.
You can expect to pay from US$36 to US$68 for a bus ticket from Calama to Santiago, CL based on the last 2 days. You can expect to find the cheapest price for the trip at US$36, which is on 2025-11-07.
Usually Pluss Chile will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
About Bus Travel
Bus Travel Tips
Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Calama and Santiago!
Much more than a mere vehicle taking you from Calama to Santiago, riding the bus will expose you to some of the most stunning panoramas while enroute to your final bus stop.
Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Calama to Santiago.
Make a music playlist for your bus ride from Calama to Santiago, and enjoy the scenery to tunes from your own personal soundtrack.
Did you know?
Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!
The average number of passengers on a coach bus is 32 meaning that a bus could replace a minimum of at least 30 cars!
9.2% of ground transportation in Europe is done by bus versus 7.4% by train.
Top travelled bus routes
Why choose Busbud?
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Popular Buses Connecting Calama
Buses Leaving from Calama
- Bus from Calama to Iquique
- Coach Calama - La Serena
- Bus Calama - Antofagasta
- Bus from Calama to Sierra Gorda
- Coach Calama - Copiapo
- Bus Calama - Santiago
- Bus from Calama to Ovalle
- Coach Calama - Los Vilos
- Bus Calama - Vina del Mar
- Bus from Calama to Vallenar
- Coach Calama - Quillota
- Bus Calama - La Calera
- Bus from Calama to Baquedano
- Coach Calama - Pozo Almonte
- Bus Calama - Taltal
Buses Going to Calama
- Bus from Copiapo to Calama
- Coach Iquique - Calama
- Bus Uyuni - Calama
- Bus from Sierra Gorda to Calama
- Coach Coquimbo - Calama
- Bus Salta - Calama
- Bus from Valdivia to Calama
- Coach Quillota - Calama
- Bus Taltal - Calama
- Bus from Ovalle to Calama
- Coach Pozo Almonte - Calama
- Bus Osorno Province - Calama
- Bus from Baquedano to Calama
- Coach Puerto Montt - Calama
- Bus Alto Hospicio - Calama
Popular Buses Connecting Santiago
Buses Leaving from Santiago
- Bus from Santiago to Puerto Montt
- Coach Santiago - Concepción
- Bus Santiago - Antofagasta
- Bus from Santiago to Mendoza
- Coach Santiago - La Serena
- Bus Santiago - Temuco
- Bus from Santiago to Los Alamos
- Coach Santiago - La Boca
- Bus Santiago - Licanray
- Bus from Santiago to Laraquete
- Coach Santiago - Carahue
- Bus Santiago - Quintero
- Bus from Santiago to Valparaiso
- Coach Santiago - Cholchol
- Bus Santiago - Coronel
Buses Going to Santiago
- Bus from Victoria to Santiago
- Coach Concepción - Santiago
- Bus Mendoza - Santiago
- Bus from Castro to Santiago
- Coach Valdivia - Santiago
- Bus Antofagasta - Santiago
- Bus from Labranza to Santiago
- Coach Pupuya - Santiago
- Bus La Boca - Santiago
- Bus from Alto Hospicio to Santiago
- Coach Vicuña - Santiago
- Bus Matanzas - Santiago
- Bus from Los Lagos to Santiago
- Coach Casablanca - Santiago
- Bus Purén - Santiago