Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Tampa Bus Station | Bus station | CheapestFastest | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tampa Bus Station | Bus station | No tags | ||||
| Bus | University of South Florida | Bus station | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Tampa Bus Station | Bus station | No tags | ||||
Greyhound Lines, Inc. + FlixBus | Bus | Tampa Bus Station | Florence, SC | No tags |
Last refresh of the prices: Today at 10:29 EST.
Compare 2 ways to travel from Tampa to Florence
Among the sustainable travel choices, the Train stands out as a good way to reach Florence. The journey takes about 18 hours and with fares starting at just £56, it presents an excellent value for a comfortable ride.
Where are the popular stops in Tampa and Florence?
Stops in Tampa
- A
Tampa 13th Avenue Bus Stop (McDonald's)
2101 E 13th Ave (McDonald's), Tampa, FL 33605 - B
Tampa USF, FL
3801 USF Holly Drive, Tampa., FL 33620, USA - C
Greyhound Station
610 E Polk St, Tampa, FL 33602, USA - D
E Sligh Ave
11555 E Sligh Ave, Seffner, FL 33584, USA - E
N Marion St & E Laurel St
551 E Laurel St, Tampa, FL 33602, USA - F
Port of Tampa
200-298 FL-60, Tampa, FL 33602, USA
Stops in Florence
- A619 S Irby St, Florence, SC 29501, USA
- B
TA Travel Center - Florence
2301 W Lucas St, Florence, SC 29501, USA
Compare bus companies
Frequently asked questions about travelling by bus from Tampa to Florence, SC, US
Please note that timetables, routes, or operator details shown here may be updated or vary at the time of your journey.
How much is the bus ticket from Tampa to Florence?
The cheapest coach tickets from Tampa to Florence start from £61. The average price for this route is around £97. Busbud recommends that you book your tickets in advance for a better chance to get the lowest possible price.
How long is the bus journey from Tampa to Florence?
The average bus journey time from Tampa to Florence is 20h 5m, covering a distance of 459 miles. The fastest bus can take you there in 12h 57m and is operated by Amtrak.
Which bus companies service the Tampa to Florence route?
What is the earliest and latest departure time for the bus from Tampa to Florence?
The earliest bus departs from Tampa to Florence at 06:50. And the latest bus departs at 22:35.
What are the CO₂ emissions for the bus trip from Tampa to Florence?
A bus journey from Tampa to Florence produces an estimated 18 kg of CO₂, making it a highly eco-friendly choice and a mode of travel recommended by Busbud.
Which is the best bus company from Tampa to Florence?
According to Busbud customers, the highest-rated bus company on this route is Amtrak, with an average rating of 4.1 out of 5 stars based on 5733 reviews.
Which company has the best Wi-Fi from Tampa to Florence?
Based on Busbud reviews, the bus company Amtrak has the best Wi-Fi rating with a score of 3.6.
Which bus company offers the most punctual service from Tampa to Florence?
According to Busbud traveller reviews, the most punctual bus company on this route is FlixBus, with a punctuality rating of 3.9 out of 5 stars.
Which bus company has the cleanest buses from Tampa to Florence?
According to Busbud traveller reviews, the bus company with the cleanest buses on this route is Amtrak, with a cleanliness rating of 4.5 out of 5 stars.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Tampa to Florence, SC, US was searched and found on 25 Jan 2026 with a price of £58To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tampa to Florence, SC, US as early as possible.
You can expect to pay from £58 to £356 for a bus ticket from Tampa to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at £58, which is on 2026-01-25.
Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Tampa to Florence, SC, US?
The Bus is the cheapest travel choice for this destination
