Find coaches from Tampa to Florence, SC, US

Next departures

Next departures from Tampa to Florence on 14 October
Operated byVehicle typeDeparture timeDeparture locationTrip durationArrival timeArrival locationRecommendedPrice and booking link
FlixBus
Tampa Bus Station
Bus stationCheapest
Amtrak
Union Station
Florence StationFastest
Amtrak
Union Station
Florence StationNo tags
FlixBus + Greyhound Lines, Inc.
University of South Florida
Bus stationNo tags

Last refresh of the prices: Today at 16:29 EDT.

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Compare 2 ways to travel from Tampa to Florence

Bus
Average priceUS$56 - US$135Average duration18h 15m
18kg CO₂e5 out of 5 stars
CheapestMost eco-friendly
Train
Average priceUS$93 - US$93Average duration18h 4m
67kg CO₂e1 out of 5 stars
Fastest
busbud logoBusbud recommends taking the bus from Tampa to Florence

Among the sustainable travel choices, the bus stands out as a good way to reach Florence. The journey takes about 18 hours 15 minutes and with fares starting at just US$56, it presents an excellent value for a comfortable ride.

4bus per day
18h 15mAverage duration
US$56Cheapest ticket
18kgCO₂ emissions

Bus Tampa to Florence, SC, US: Trip Overview

Average ticket priceUS$75
Average bus trip duration18h 15m
Number of daily buses4
Earliest bus departure09:30
Distance451 miles
Latest bus departure22:35

Tampa to Florence Bus

Busbud helps you find a bus from Tampa to Florence. Get the best fare and schedule, book a round trip ticket or find buses with WiFi and electrical outlets.

We make it our job to connect you with the most dependable bus companies that cover bus service from Tampa to Florence.

Whether it is cheap bus tickets or more luxurious buses going to Florence from Tampa, we help you find what you're looking for based on how much of a budget you have.

Frequently asked questions on the trip Tampa - Florence, SC, US

  1. How far is Florence from Tampa by coach?

    The journey from Tampa to Florence by coach covers an approximate distance of 464 miles (747 km).

  2. Is there a way to reach Florence from Tampa without flying?

    To travel from Tampa to Florence without flying, you can take the coaches. Choosing the coach guarantees a comfortable and sustainable travel experience, allowing you to admire the views on your way to your destination. You also have the option of utilising carpooling services.

Find cheapest prices for buses

Price is for a one-way ticket for one passenger and based on past searches.

Best price found
11/10
No data
12/10
No data
Today
No data
14/10
US$92
15/10
No data
16/10
No data
17/10
US$68
18/10
US$50
busbud logoThe cheapest trip from Tampa to Florence, SC, US was searched and found on 18 Oct 2025 with a price of US$50

To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Tampa to Florence, SC, US as early as possible.

You can expect to pay from US$50 to US$465 for a bus ticket from Tampa to Florence, SC, US based on the last 2 days. You can expect to find the cheapest price for the trip at US$50, which is on 2025-10-18.

Usually Amtrak will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.

About Bus Travel

Bus Travel Tips

Make friends with the driver. They usually know a lot about your destination and may even recommend which side of the bus to sit on to get the best views on the road between Tampa and Florence!

From miles long of beauteous natural landscapes to impressive man-crafted sights, you’re bound to be in for a visual treat on your bus trip from Tampa to Florence.

Buses are energy-efficient. Carrying a passenger over 100 kms by coach only takes 0.6-0.9 liters of gas. Compare that to the 2.6 liters required by high-speed train, 6.6 liters by airplane and 7.6 liters by gas-powered car, and it's clear that the bus is a more environmentally-conscious option for your bus transportation from Tampa to Florence.

Create your own real life musical score by curating a personalized bus travel playlist - the perfect accompaniment to your bus ride from Tampa to Florence.

Did you know?

Did you know there are on average 4,400 intercity bus departures every day in the US only? This number has been growing for 9 years in a row, yay!

One of the longest bus route in the world goes all the way from Ontario to Alberta in Canada (with the same bus). This trip is 3,435 km or 2,135 miles long and the price is a bit under $100.

The word 'bus' is an abbreviation of 'omnibus" which means 'for all' in Latin as buses were meant to be transportation for everybody.

What's the cheapest way to go from Tampa to Florence, SC, US?

busbud logoThe bus is the cheapest travel choice for this destination

Will you be returning to Tampa by bus?

Bus from Florence, SC, US to Tampa

You can also go to Florence, SC, US by train

Train from Tampa to Florence, SC, US

Why choose Busbud?

The Best Way To Book Bus and Train Tickets

Busbud makes bus travel easy. We help travellers find a bus, plot routes, and book intercity bus tickets all over the world. Use Busbud to book your trip online, in your own language and currency, wherever you are. Busbud prides itself on its worldwide partnerships. We make it possible for you to buy tickets with its large network of trustworthy bus partners like Greyhound, Eurolines, ALSA, OUIBUS (BlaBlaBus), National Express and many others.

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