Next train departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Train | Hlavní nádraží | Brussels South/Midi Train Station | Cheapest | ||||
EuroCity Train + InterCity + Regional-Express + Deutsche Bahn ICE | Train | Hlavní nádraží | Brussels Central Train Station | Fastest | ||||
| Train | Hlavní nádraží | Brussels South/Midi Train Station | No tags | ||||
EuroCity Train + InterCity + Regional-Express + Deutsche Bahn ICE | Train | Hlavní nádraží | Schaarbeek | No tags | ||||
EuroCity Train + InterCity + Regional-Express + Deutsche Bahn ICE | Train | Hlavní nádraží | Schaarbeek | No tags |
Last refresh of the prices: Last Friday at 22:33 CET.
Compare 2 ways to travel from Prague to Brussels
Among the sustainable travel choices, the bus stands out as a good way to reach Brussels. The journey takes about 18 hours 40 minutes and with fares starting at just £34, it presents an excellent value for a comfortable ride.
Where are the popular train stations and stops in Prague and Brussels?
Prague
- A300/8 Wilsonova, 110 00 Praha, Czechia
- BKřižíkova 2b, Nové Město, 186 00 Praha-Praha 8, Czech Republic
- CAviatická, 161 08, Praha 6, Czechia
- DChlumecká, 198 00 Praha 20, Czech Republic
- ETomíčkova 2234, Chodov, 148 00 Praha-Praha 11, Czechia
- F
Praha-Smichov
Praha-Smíchov, 150 00 Praha-Praha 5, Czechia
Brussels
- ABoulevard Simon Bolivar 7, 1030 Schaerbeek, Belgium
- BRue de France 85, 1060 Saint-Gilles, Belgium
- C
Bruxelles / Brussels Central
Brussel-Centraal, Carrefour de l'Europe, 1000 Bruxelles, Belgium
Frequently asked questions about travelling from Prague to Brussels by train
How much does a cheap train ticket from Prague to Brussels cost?
The average train ticket price from Prague to Brussels is £92. The best way to find cheap train tickets from Prague to Brussels is to book your tickets as early as possible. Prices tend to rise as your travel date approaches, so book in advance to secure the best prices!
How long is the train trip from Prague to Brussels?
A train trip between Prague and Brussels is around 15h 25m, although the fastest train will take about 11h 3m. This is the time it takes to travel the 446 miles that separates the two cities.
How many daily train are there between Prague and Brussels?
The number of trains from Prague to Brussels can differ depending on the day of the week. On average, there are 4. Some trains are direct while others include transferring trains. Simplify your train trip from Prague to Brussels by comparing and selecting the train that fits your travel style and budget on Busbud.
What are the departure and arrival stations for a train from Prague to Brussels?
Trains travelling between Prague and Brussels leave from Hlavní nádraží or Florenc and arrive at Brux-Nord, Brussels South (Gare du Midi), Bruxelles / Brussels Central.
Find cheapest prices for trains
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Prague to Brussels was searched and found on 2 Dec 2025 with a price of £120To save money and be sure you have the best seat, it's a good idea to buy your train tickets from Prague to Brussels as early as possible.
You can expect to pay from £120 to £875 for a train ticket from Prague to Brussels based on the last 2 days. You can expect to find the cheapest price for the trip at £120, which is on 2025-12-02.
