Next bus departures
| Operated by | Vehicle type | Departure time | Departure location | Trip duration | Arrival time | Arrival location | Recommended | Price and booking link |
|---|---|---|---|---|---|---|---|---|
 | Bus | Orlando Bus Station | 1116 Woodruff Rd | Cheapest | ||||
 | Bus | Orlando Bus Station | 1116 Woodruff Rd | Fastest | ||||
FlixBus + Greyhound Lines, Inc. | Bus | Orlando Bus Station | 1116 Woodruff Rd | No tags | ||||
FlixBus + Greyhound Lines, Inc. | Bus | The Florida Mall | 1116 Woodruff Rd | No tags |
Last refresh of the prices: Yesterday at 18:00 EST.
Compare 2 ways to travel from Orlando to Greenville
Among the sustainable travel choices, the bus stands out as a good way to reach Greenville. The journey takes about 11 hours 55 minutes and with fares starting at just £54, it presents an excellent value for a comfortable ride.
Where are the popular stops in Orlando and Greenville?
Stops in Orlando
- A555 N John Young Pkwy, Orlando, FL 32805
- BRedCoach Station, 1777 McCoy Road, Orlando, FL 32809
- CJet Set Express Terminal, 3718 LB Mcleod Rd., 32805 Orlando, FL,, United States
- D
Disney World
Disney's All-Star Sports Resort, 1701 West Buena Vista Dr., Orlando, FL 32830 - E
International Dr SuperTours Terminal
5419 International Dr, Orlando, FL 32819, USA - F
Seaworld Hotels
10100 International Drive , Orlando, 32821
Stops in Greenville
- A
Guadalajara Supermarket Bus Stop
2803 White Horse Rd, Greenville, SC 29611 - B
Greenville Bus Station
9 Hendrix DR, Greenville, SC 29607
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Frequently asked questions about travelling by bus from Orlando to Greenville, SC
What's the distance between Orlando and Greenville by coach?
The journey from Orlando to Greenville by coach covers an approximate distance of 440 miles (710 km).
What is the best way to go from Orlando to Greenville without flying?
To travel from Orlando to Greenville without flying, you can take the coaches. The coach provides a comfortable and sustainable journey and allows you to enjoy the sights while reaching your destination. You might also find carpooling options to travel between the two cities.
Find cheapest prices for buses
Price is for a one-way ticket for one passenger and based on past searches.
The cheapest trip from Orlando to Greenville, SC was searched and found on 27 Nov 2025 with a price of £79To save money and be sure you have the best seat, it's a good idea to buy your bus tickets from Orlando to Greenville, SC as early as possible.
You can expect to pay from £79 to £169 for a bus ticket from Orlando to Greenville, SC based on the last 2 days. You can expect to find the cheapest price for the trip at £79, which is on 2025-11-27.
Usually Greyhound will charge you higher prices for tickets closer to the departure date. To find the best prices, you should be flexible on your date of travel.
What's the cheapest way to go from Orlando to Greenville, SC?
The bus is the cheapest travel choice for this destination
